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Emerging Microencapsulated Apricot Kernel Powder Improves Biochemical Parameters in Rats
Emerging Materials Research ( IF 2.2 ) Pub Date : 2020-10-21 , DOI: 20.00258 Ercan Karabulut
Emerging Materials Research ( IF 2.2 ) Pub Date : 2020-10-21 , DOI: 20.00258 Ercan Karabulut
This study appears to be the first attempt to use a novel microencapsulated apricot kernel powder (MAKP) to improve diabetes and obesity-related parameters in serum and liver tissue of normal and cafeteria diet-fed rats. For this purpose, bitter apricot kernel powder (AKP) was microencapsulated within maltodextrin matrix under optimized conditions and the effects of treatment with microencapsulated apricot kernel powder (MAKP) at two doses (4 and 8 mg) on the parameters in normal and cafeteria diet-fed rats were established. MAKP was characterized in terms of its molecular properties, revealing that AKP could be successfully encapsulated. MAKP was established to have a clear effect to increase (P <0.01) levels of native thiol, total thiol, TAS, HDL and thioredoxin reductase parameters, and to decrease (P <0.01) the levels of TOS, disulfide, Index I and II, OSI, total cholesterol, LDL, glucose, triglyceride, CAT, SOD, TNF a and GSH Px parameters; however, these effects were dose-independent and more prominent in the rats fed cafeteria diet. As a consequence, use of MAKP significantly (P <0.01) improved these parameters in the rats fed cafeteria diet, suggesting that use of MAKP may contribute to the current efforts that are being exerted to treat diabetes and obesity-related disorders.
中文翻译:
新兴的微囊化杏仁粉改善大鼠的生化指标
这项研究似乎是首次尝试使用新型微囊化杏仁粉(MAKP)来改善正常和食堂饮食喂养的大鼠的血清和肝组织中与糖尿病和肥胖相关的参数。为此,将苦杏仁仁粉(AKP)在最佳条件下微囊化在麦芽糖糊精基质中,并以两种剂量(4和8 mg)的微囊杏仁粉(MAKP)处理正常和自助餐厅饮食中的参数,建立喂食的大鼠。MAKP的分子特性进行了表征,表明AKP可以成功地被封装。建立MAKP具有明显的作用,可提高(P <0.01)天然硫醇,总硫醇,TAS,HDL和硫氧还蛋白还原酶参数的水平,并降低(P <0.01)TOS,二硫键,指标I和II,OSI,总胆固醇,LDL,葡萄糖,甘油三酸酯,CAT,SOD,TNF a和GSH Px参数; 但是,这些作用与剂量无关,在以食堂饮食喂养的大鼠中更为明显。因此,使用MAKP可以显着改善(P <0.01)食堂饮食大鼠的这些参数,这表明使用MAKP可能有助于当前为治疗糖尿病和肥胖相关疾病所做的努力。
更新日期:2020-10-30
中文翻译:
新兴的微囊化杏仁粉改善大鼠的生化指标
这项研究似乎是首次尝试使用新型微囊化杏仁粉(MAKP)来改善正常和食堂饮食喂养的大鼠的血清和肝组织中与糖尿病和肥胖相关的参数。为此,将苦杏仁仁粉(AKP)在最佳条件下微囊化在麦芽糖糊精基质中,并以两种剂量(4和8 mg)的微囊杏仁粉(MAKP)处理正常和自助餐厅饮食中的参数,建立喂食的大鼠。MAKP的分子特性进行了表征,表明AKP可以成功地被封装。建立MAKP具有明显的作用,可提高(P <0.01)天然硫醇,总硫醇,TAS,HDL和硫氧还蛋白还原酶参数的水平,并降低(P <0.01)TOS,二硫键,指标I和II,OSI,总胆固醇,LDL,葡萄糖,甘油三酸酯,CAT,SOD,TNF a和GSH Px参数; 但是,这些作用与剂量无关,在以食堂饮食喂养的大鼠中更为明显。因此,使用MAKP可以显着改善(P <0.01)食堂饮食大鼠的这些参数,这表明使用MAKP可能有助于当前为治疗糖尿病和肥胖相关疾病所做的努力。