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Alterations in the Blood Parameters and Fecal Microbiota and Metabolites during Pregnant and Lactating Stages in Bama Mini Pigs as a Model
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-10-26 , DOI: 10.1155/2020/8829072 Cui Ma 1, 2 , QianKun Gao 1 , WangHong Zhang 1, 2 , Md Abul Kalam Azad 1 , XiangFeng Kong 1
Mediators of Inflammation ( IF 4.6 ) Pub Date : 2020-10-26 , DOI: 10.1155/2020/8829072 Cui Ma 1, 2 , QianKun Gao 1 , WangHong Zhang 1, 2 , Md Abul Kalam Azad 1 , XiangFeng Kong 1
Affiliation
This study was conducted to analyze plasma reproductive hormone and biochemical parameter changes, as well as fecal microbiota composition and metabolites in sows, at different pregnancy and lactation stages, using Bama mini pig as an experimental animal model. We found that plasma prolactin (PRL), progesterone, follicle-stimulating hormone (FSH), and estrogen levels decreased from day 45 to day 105 of pregnancy. Plasma total protein and albumin levels were lower in pregnant sows, while glucose, urea nitrogen, total cholesterol, and high-density lipoprotein-cholesterol, as well as fecal acetate, butyrate, valerate, total short-chain fatty acids, skatole, and tyramine levels, were higher in lactating sows. Interestingly, the lactating sows showed lower α-diversity and Spirochaetes and Verrucomicrobia relative abundances, while pregnant sows showed a higher Proteobacteria relative abundance. Notably, the Akkermansia relative abundance was highest on day 7 of lactation. Spearman analysis showed a positive correlation between plasma triglyceride and cholinesterase levels and Akkermansia and Streptococcus relative abundances. Moreover, Oscillospira and Desulfovibrio relative abundances were also positively correlated with plasma FSH, LH, and E2 levels, as well as PRL and LH with Bacteroides. Collectively, plasma reproductive hormones, biochemical parameters, and fecal microbiota composition and metabolite levels could alter along with pregnancy and lactation, which might contribute to the growth and development demands of fetuses and newborns.
中文翻译:
以巴马小型猪为模型的妊娠期和哺乳期血液参数和粪便微生物群和代谢物的变化
本研究以巴马小型猪为实验动物模型,分析母猪在不同妊娠和哺乳阶段的血浆生殖激素和生化参数变化,以及粪便微生物群组成和代谢物。我们发现血浆催乳素 (PRL)、孕酮、促卵泡激素 (FSH) 和雌激素水平从怀孕第 45 天到第 105 天下降。怀孕母猪的血浆总蛋白和白蛋白水平较低,而葡萄糖、尿素氮、总胆固醇和高密度脂蛋白胆固醇,以及粪便乙酸盐、丁酸盐、戊酸盐、总短链脂肪酸、粪臭素和酪胺水平,在泌乳母猪中更高。有趣的是,泌乳母猪显示出较低的α-多样性和螺旋体和Verrucomicrobia相对丰度,而怀孕母猪显示更高的Proteobacteria相对丰度。值得注意的是,Akkermansia相对丰度在哺乳第 7 天最高。Spearman 分析显示血浆甘油三酯和胆碱酯酶水平与阿克曼氏菌和链球菌的相对丰度呈正相关。此外,Oscillospira和Desulfovibrio 的相对丰度也与血浆 FSH、LH 和 E 2水平以及 PRL 和 LH 与拟杆菌呈正相关。 总的来说,血浆生殖激素、生化参数、粪便微生物群组成和代谢物水平可能会随着怀孕和哺乳而改变,这可能有助于胎儿和新生儿的生长和发育需求。
更新日期:2020-10-30
中文翻译:
以巴马小型猪为模型的妊娠期和哺乳期血液参数和粪便微生物群和代谢物的变化
本研究以巴马小型猪为实验动物模型,分析母猪在不同妊娠和哺乳阶段的血浆生殖激素和生化参数变化,以及粪便微生物群组成和代谢物。我们发现血浆催乳素 (PRL)、孕酮、促卵泡激素 (FSH) 和雌激素水平从怀孕第 45 天到第 105 天下降。怀孕母猪的血浆总蛋白和白蛋白水平较低,而葡萄糖、尿素氮、总胆固醇和高密度脂蛋白胆固醇,以及粪便乙酸盐、丁酸盐、戊酸盐、总短链脂肪酸、粪臭素和酪胺水平,在泌乳母猪中更高。有趣的是,泌乳母猪显示出较低的α-多样性和螺旋体和Verrucomicrobia相对丰度,而怀孕母猪显示更高的Proteobacteria相对丰度。值得注意的是,Akkermansia相对丰度在哺乳第 7 天最高。Spearman 分析显示血浆甘油三酯和胆碱酯酶水平与阿克曼氏菌和链球菌的相对丰度呈正相关。此外,Oscillospira和Desulfovibrio 的相对丰度也与血浆 FSH、LH 和 E 2水平以及 PRL 和 LH 与拟杆菌呈正相关。 总的来说,血浆生殖激素、生化参数、粪便微生物群组成和代谢物水平可能会随着怀孕和哺乳而改变,这可能有助于胎儿和新生儿的生长和发育需求。