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Muscle Injury in Bodybuilding Based on Mesoporous Multifunctional Nanomaterials for Sports Rehabilitation Training
Journal of Chemistry ( IF 3 ) Pub Date : 2020-10-23 , DOI: 10.1155/2020/1784036
Changjun Zhao 1
Affiliation  

As an important means of treating diseases, chemical-based drugs have always guaranteed people’s health and longevity. However, due to the nature of some drugs, their use in the medical field is limited. This study mainly discusses the treatment of muscle damage based on sports rehabilitation training mesoporous multifunctional nanomaterials in bodybuilding. The biological characteristics of the targeted control of mesoporous multifunctional nanomaterials for target drugs were studied by analyzing the regeneration of skeletal muscles of mice after gastrocnemius strain under computer control. The electrostatic interactions modified by the consensus binding between AS1411 and Dimer-PPTcDA on the surface of mesoporous silicon are used to block the pores, and the release of objective molecules depends on the concentration of the drug in the tendon cells and the time of action. In this system, AS1411 has both the characteristics of the target substance and the active site of the targeted stimulus response in the cell. After FAM is labeled AS1411, the fluorescence of FAM can be used to monitor the release of the drug in real time, so as to directly release the drug to the lesion, maintain local effectiveness, and greatly improve the biological activity of the drug. In addition, in the safety analysis of mesoporous multifunctional nanomaterials on cells, if the concentration of nanoparticles is 90 μg/mL, the cell survival rate is almost 100%. The results show that the mesoporous multifunctional nanomaterials have low cytotoxicity and cell activity is not affected. The smaller the particle size of mesoporous silicon, the easier it is to invade the focus cells. In addition, confocal microscopy imaging has also effectively demonstrated the targeting effect of mesoporous multifunctional nanomaterials on cells.

中文翻译:

基于介孔多功能纳米材料的健美肌肉损伤运动康复训练

化学药物作为治疗疾病的重要手段,一直是人们健康长寿的保障。但是,由于某些药物的性质,它们在医疗领域的使用受到限制。本研究主要探讨基于运动康复训练介孔多功能纳米材料在健美中治疗肌肉损伤。通过计算机控制下小鼠腓肠肌劳损后骨骼肌的再生分析,研究了介孔多功能纳米材料靶向药物靶向调控的生物学特性。通过AS1411与介孔硅表面的Dimer-PPTcDA之间的一致结合修饰的静电相互作用用于堵塞孔隙,目标分子的释放取决于药物在肌腱细胞中的浓度和作用时间。在这个系统中,AS1411既具有目标物质的特性,又具有细胞内靶向刺激反应的活性部位。FAM被标记为AS1411后,可以利用FAM的荧光实时监测药物的释放,从而将药物直接释放到病灶,保持局部有效性,大大提高药物的生物活性。此外,在介孔多功能纳米材料对细胞的安全性分析中,如果纳米粒子的浓度为90 μg/mL,则细胞存活率几乎为100%。结果表明,介孔多功能纳米材料的细胞毒性低,细胞活性不受影响。介孔硅的粒径越小,越容易侵入聚焦单元。此外,共聚焦显微成像也有效证明了介孔多功能纳米材料对细胞的靶向作用。
更新日期:2020-10-23
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