Although modern antibiotics and surgical technology have made great progress, when using carbon nanomaterials to treat bone marrow-induced inflammation after martial arts fractures, how to simultaneously repair bone defects and control wound infections is the current focus of orthopedics research. This paper uses electrospinning technology to develop a carbon nanomaterial based on PLA, HA-g-PLA, and vancomycin. The surface morphology, biocompatibility, drug release, and osteogenesis of carbon nanomaterials are studied, selecting animal models to verify its effect in the treatment of osteomyelitis with bone defects and provide new ideas and new methods for the treatment of bone defects complicated by osteomyelitis infection. In this paper, carbon nanofibers containing doxycycline, a small molecule protease inhibitor, were prepared by simple blending. Encapsulation of carbon nanofibers can control the slow release of doxycycline and improve the effect of doxycycline in treating chronic wounds. This article uses two methods to prepare different types of osteomyelitis models and compare them. After injecting saline or bacterial solution, the two groups were sealed with bone wax and the incision was closed; the blank group did not do any treatment. Within 30 days after surgery, the appearance of the left hind limb wound and general signs of infection were closely monitored, body temperature was measured, and blood was collected from the ear veins of experimental animals to analyze the changes in C-reactive protein (CRP) and procalcitonin levels (PCT); X-ray, CT imaging, and histological observation were performed on 14 and 28 days. Studies have shown that when the drug loading of doxycycline increases from 10% to 15%, this is related to the change in properties of the polylactic acid fiber membrane from hydrophobic to hydrophilic caused by the increase in doxycycline drug loading.

中文翻译：

---

碳纳米材料治疗武术骨折后感染性骨缺损及伤口瘢痕

尽管现代抗生素和外科技术取得了长足的进步，但在使用碳纳米材料治疗武术骨折后骨髓引起的炎症时，如何同时修复骨缺损和控制伤口感染是目前骨科研究的重点。本文利用静电纺丝技术开发了一种基于 PLA、HA-g-PLA 和万古霉素的碳纳米材料。研究碳纳米材料的表面形貌、生物相容性、药物释放、成骨等，选择动物模型验证其治疗骨髓炎伴骨缺损的效果，为治疗并发骨髓炎感染的骨缺损提供新思路和新方法。在本文中，含有多西环素的碳纳米纤维，一种小分子蛋白酶抑制剂，通过简单的混合制备。碳纳米纤维的包封可以控制强力霉素的缓慢释放，提高强力霉素治疗慢性伤口的效果。本文采用两种方法制备不同类型的骨髓炎模型并进行比较。注射生理盐水或菌液后，两组均用骨蜡封口，关闭切口；空白组不做任何处理。术后30天内，严密监测左后肢伤口外观及一般感染体征，测量体温，并从实验动物耳静脉采血分析C反应蛋白（CRP）变化。 ) 和降钙素原水平 (PCT); 在第 14 天和第 28 天进行 X 射线、CT 成像和组织学观察。