当前位置: X-MOL 学术Dis. Markers › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Clinical Value and Variation of Antithyroid Antibodies during Pregnancy
Disease Markers ( IF 3.464 ) Pub Date : 2020-10-22 , DOI: 10.1155/2020/8871951
Chuyu Li 1, 2, 3 , Jing Zhou 1, 2, 3 , Zengshu Huang 1, 2, 3 , Xinyao Pan 1, 2, 3 , Wingting Leung 1, 2, 3 , Lijia Chen 1, 2, 3 , Yanzhi Zhang 1, 2, 3 , Lan Wang 1, 2, 3 , Yizhen Sima 1, 2, 3 , Hans-Jürgen Gober 4 , Na Zhang 1, 2, 3 , Xuemin Qiu 1, 2, 3 , Lisha Li 1, 2, 3 , Liang Guan 5, 6 , Ling Wang 1, 2, 3
Affiliation  

Antithyroid antibodies, which include thyroid-stimulating hormone receptor antibodies (TRAbs), thyroid peroxidase antibodies (TPOAbs), and thyroid globulin antibodies (TgAbs), are widely known for their tight association with thyroid autoimmune diseases. The variation in all three kinds of antibodies also showed different trends during and after pregnancy (Weetman, 2010). This article reviewed the the physiological changes, while focusing on the variation of thyroid antibodies concentration in women during and after pregnancy, and adverse consequences related to their elevation. Since abnormal elevations of these antithyroid antibodies may lead to adverse outcomes in both mothers and fetuses, special attention must be paid to the titer of the antibodies during pregnancy. The molecular mechanisms of the variations in those antibodies have yet to be explained. The frequency and timing of thyroid antibody measurement, as well as different reference levels, also remain to be elucidated.

中文翻译:

妊娠期抗甲状腺抗体的临床价值及变异

抗甲状腺抗体包括促甲状腺激素受体抗体 (TRAbs)、甲状腺过氧化物酶抗体 (TPOAbs) 和甲状腺球蛋白抗体 (TgAbs),因其与甲状腺自身免疫性疾病的密切关系而广为人知。所有三种抗体的变化在怀孕期间和之后也表现出不同的趋势(Weetman,2010)。本文综述了其生理变化,重点关注女性妊娠期和妊娠后甲状腺抗体浓度的变化,以及与其升高相关的不良后果。由于这些抗甲状腺抗体的异常升高可能导致母亲和胎儿的不良后果,因此在怀孕期间必须特别注意抗体的滴度。这些抗体变异的分子机制尚未得到解释。甲状腺抗体测量的频率和时间以及不同的参考水平也有待阐明。
更新日期:2020-10-30
down
wechat
bug