Stimuli-responsive microcarriers have received considerable attention in a variety of fields, including disease diagnosis, drug delivery, sensing, and imaging. Here, we report the generation of multiple-responsive perfluorocarbon-loaded magnetic hydrogel microcapsules (PMHMs) with uniform size for magnetic controlled ultrasound (US) and laser activation. The PMHMs are fabricated by a novel coaxial interface shearing (CIS) method based on the mechanism of liquid bridge formation and fracture. Perfluorocarbon and iron oxide magnetic nanoparticles are used as US-responsive and photothermal absorption medium, respectively, and magnetic nanoparticles are also used for magnetic-controlled targeting. Moreover, the size, structure, and function of the prepared biocompatible PMHMs can be precisely controlled by adjusting the process parameters of CIS. It is indicated that the PMHMs have different US- and light-responsive characteristics, mainly because of the difference of their activation mechanisms. It is demonstrated that laser has better activation resolution and can achieve site-specific activation and drug release of PMHMs. The multiple-responsive features imply that the PMHMs fabricated by CIS may provide an effective drug release platform for biomedical and pharmaceutical applications.

刺激响应性微载体在疾病诊断，药物输送，传感和成像等各个领域都受到了广泛的关注。在这里，我们报告的磁控超声（US）和激光激活具有大小均一的多重响应的全氟化碳负载的磁性水凝胶微胶囊（PMHM）的生成。基于液桥形成和断裂的机理，通过新颖的同轴界面剪切（CIS）方法制造了PMHM。全氟化碳和氧化铁磁性纳米颗粒分别用作US响应和光热吸收介质，磁性纳米颗粒也用于磁性控制的靶向。此外，可以通过调节CIS的工艺参数来精确控制制备的生物相容性PMHM的尺寸，结构和功能。结果表明，PMHMs具有不同的美国和光响应特性，这主要是由于它们的激活机制不同。结果表明，激光具有更好的激活分辨率，可以实现PMHMs的位点激活和药物释放。多重响应特征表明，由CIS制造的PMHM可为生物医学和制药应用提供有效的药物释放平台。