Olanzapine (OLZ), one of the second-generation antipsychotics, is effective in stress accompanying with chronic psychiatric disease. But the effect of chronic long-standing use of OLZ administration on the liver and its association with metabolic side effects plus weight gain is still unclear. The objective of our study was to evaluate the antioxidant effect of Hypericum perforatum (HP) on OLZ-induced oxidative stress, biochemical disturbance, and histological alteration in the rat’s liver. Forty male wistar albino rats were allocated as follows: normal control rats (group 1), rats treated with OLZ at a dose of 27.0 mg/kg/day (group 2), group 3 (treated with HP at a dose of 81.0 mg/kg/day) and group 4 (received HP plus OLZ at the same doses). The results revealed that the OLZ-administration led to a significant elevation (***P < 0.001) in the levels of MDH, blood glucose, triglycerides, total cholesterol, liver function parameters and weight gain while a significant decrease (***P < 0.001) in activities of liver SOD and GSH was found. In addition to structural damage in the liver’s tissue. These findings were evaluated the toxic effects of chronic administration of OLZ. While HP supplementation caused a significant improvement (⁺⁺P <0.05, ⁺⁺⁺P < 0.001) in liver biomarkers, metabolic parameters, and oxidative stress index besides inhibit the histological damage of liver tissue.

奥氮平（OLZ）是第二代抗精神病药之一，可有效缓解慢性精神病患者的精神压力。但是，长期长期服用OLZ对肝脏的影响及其与代谢副作用和体重增加的关​​系尚不清楚。我们研究的目的是评估贯叶连翘的抗氧化作用（HP）对OLZ诱导的大鼠肝脏氧化应激，生化紊乱和组织学改变的影响。如下分配40只雄性wistar白化病大鼠：正常对照大鼠（第1组），以27.0 mg / kg /天的剂量用OLZ治疗的大鼠（第2组），第3组（用81.0 mg / kg的HP治疗）公斤/天）和第4组（以相同剂量接受HP加OLZ）。结果显示，OLZ给药导致MDH，血糖，甘油三酸酯，总胆固醇，肝功能参数和体重增加显着升高（*** P <0.001），而显着降低（*** P <0.001）在肝脏中发现了SOD和GSH的活性。除了肝脏组织的结构性损伤。这些发现评估了长期服用OLZ的毒性作用。补充HP不仅可以抑制肝组织的组织学损伤，还可以在肝脏生物标志物，代谢参数和氧化应激指数方面显着改善（⁺⁺ P <0.05，⁺⁺⁺ P <0.001）。