Abstract

This article describes synthesis, characterization, antimicrobial, drug-releasing and anti-cancer activity of acrylate monomer and its polymer containing chalcone moiety. The synthesized polymers were characterized through IR, ¹H NMR and UV–visible spectroscopy techniques. The molecular weight of the obtained polymer is found to be around 4000 g/mol. The synthesized polymers are thermally stable up to 260 °C. The monomer and its polymer show higher activity against gram-negative bacteria and these compounds show remarkable activity over breast cancer cells. The synthesized monomer and polymers showed higher anticancer activity. The inhibitory potential of monomers and polymers premeditated using optimized in vitro evaluation MTT assay and live cell images. The drug release potential was controlled through co-monomer, pH and temperature.

摘要

本文介绍了丙烯酸酯单体及其含有查耳酮部分的聚合物的合成、表征、抗菌、药物释放和抗癌活性。合成的聚合物通过红外、¹ H 核磁共振和紫外-可见光谱技术进行了表征。发现所得聚合物的分子量约为4000g/mol。合成的聚合物在高达 260 °C 的温度下是热稳定的。单体及其聚合物对革兰氏阴性菌显示出更高的活性，这些化合物对乳腺癌细胞显示出显着的活性。合成的单体和聚合物显示出更高的抗癌活性。体外优化的单体和聚合物的抑制潜力评估 MTT 测定和活细胞图像。通过共聚单体、pH 值和温度控制药物释放潜力。