Abstract

Nanofibrous scaffold was electrospun by blending PCL and gelatin. Nanofibers were bead-free and showed homogenous morphology with an average diameter of 320 ± 80 nm. Different concentrations of curcumin were loaded in PLA microparticles in the electrospraying process. Particles showed spherical morphology and the average diameter of 3.7 µm. The scaffold was electrospun using two-nozzles in which PLA particles sprayed among PCL/gelatin nanofibers. Finally, the scaffold was cross-linked via glutaraldehyde vapor. A very slow release manner was seen in the release profile within 35 days. Mechanical properties and cell assessment study showed that the scaffold has great potential for skin application.

摘要

通过混合 PCL 和明胶来静电纺丝纳米纤维支架。纳米纤维不含珠粒，形态均一，平均直径为 320 ± 80 nm。在电喷雾过程中，不同浓度的姜黄素被加载到 PLA 微粒中。颗粒呈球形，平均直径为 3.7 µm。支架使用双喷嘴静电纺丝，其中 PLA 颗粒喷洒在 PCL/明胶纳米纤维之间。最后，支架通过戊二醛蒸气交联。在 35 天内的释放曲线中看到了非常缓慢的释放方式。力学性能和细胞评估研究表明，该支架具有巨大的皮肤应用潜力。