Abstract

Chronic, non-healing diabetic wounds put a massive economic burden on health services causing patient incompliance and discomfort. Thorough interpreting of chronic wound pathophysiology led to the fabrication of targeted systems of drug delivery that can improve and accelerate the wound healing process. Natural polymers or biopolymers are now explored for the fabrication of wound dressings. Hence, in this review article, the pathophysiological aspects of chronic wounds, current treatment approaches, and potential biomaterials employed for treating wounds are explicated. The main emphasis is on biopolymers which aid in creating innovative systems based on nanotechnology for effective skin generation in chronic wounds.

摘要

慢性、不愈合的糖尿病伤口给卫生服务带来了巨大的经济负担，导致患者不依从和不适。对慢性伤口病理生理学的彻底解释导致制造了靶向给药系统，可以改善和加速伤口愈合过程。现在正在探索天然聚合物或生物聚合物用于制造伤口敷料。因此，在这篇综述文章中，阐述了慢性伤口的病理生理学方面、当前的治疗方法以及用于治疗伤口的潜在生物材料。主要重点是有助于创建基于纳米技术的创新系统的生物聚合物，以在慢性伤口中有效地生成皮肤。