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Effects of GST null genotypes on individual susceptibility to atherosclerotic cardiovascular diseases: a meta-analysis
Free Radical Research ( IF 3.3 ) Pub Date : 2020-10-26 , DOI: 10.1080/10715762.2019.1624743
Ying Li 1 , Li Li 1 , Duojiao Fan 1 , Zheng Wang 1, 2 , Yijie Cui 1, 2
Affiliation  

Abstract

Some genetic association studies tried to investigate potential associations between glutathione S-transferase (GST) null genotypes and atherosclerotic cardiovascular diseases (ASCVD). However, the results of these studies were not consistent. Thus, we performed the present meta-analysis to explore associations between GST null genotypes and ASCVD in a larger pooled population. Systematic literature research was performed in PubMed, Web of Science, and Embase to identify eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the strength of associations. Totally 47 studies were included for analyses. Pooled analyses suggested that GSTM1 (p = .007, OR = 1.29, 95%CI 1.07–1.56) and GSTP1 (p = .01, OR = 1.28, 95%CI 1.06–1.55) null genotypes were significantly associated with individual susceptibility to ASCVD in overall population. Further subgroup analyses revealed similar positive results for GSTM1 null genotype in South Asians and patients with coronary artery disease (CAD). No other significant results were observed for GST null genotypes in overall and subgroup analyses. In conclusion, our meta-analysis suggested that GSTM1 and GSTP1 null genotypes could impact individual susceptibility to ASCVD. These results suggested that these variations could be used to identify individuals at higher susceptibility to ASCVD.



中文翻译:

GST 无效基因型对动脉粥样硬化心血管疾病个体易感性的影响:荟萃分析

摘要

一些遗传关联研究试图调查谷胱甘肽 S 转移酶 ( GST ) 无效基因型与动脉粥样硬化性心血管疾病 (ASCVD)之间的潜在关联。然而,这些研究的结果并不一致。因此,我们进行了本荟萃分析,以在更大的合并人群中探索GST无效基因型与 ASCVD之间的关联。在 PubMed、Web of Science 和 Embase 中进行了系统的文献研究,以确定符合条件的研究。我们计算了优势比 (OR) 和 95% 置信区间 (CI) 以估计关联强度。共纳入 47 项研究进行分析。汇总分析表明GSTM1 ( p  = .007, OR = 1.29, 95% CI 1.07–1.56) 和GSTP1 ( p  = .01, OR = 1.28, 95%CI 1.06–1.55) 空基因型与总体人群中个体对 ASCVD 的易感性显着相关。进一步的亚组分析显示,南亚人和冠状动脉疾病 (CAD) 患者中GSTM1无效基因型的阳性结果相似。在总体和亚组分析中没有观察到GST无效基因型的其他显着结果。总之,我们的荟萃分析表明GSTM1GSTP1无效基因型可能会影响个体对 ASCVD 的易感性。这些结果表明,这些变异可用于识别对 ASCVD 具有更高易感性的个体。

更新日期:2020-12-09
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