OBJECTIVE The purpose of this systematic review was to examine the evidence for impaired executive functioning in patients diagnosed with a dual pathology of personality disorder (PD) and substance use disorder, and to identify whether differences exist in comparison to those with a single diagnosis. Methods: A systematic search was conducted to identify studies using measures of executive functioning in patients with PD-substance use disorder dual pathology. Sixteen studies were selected. Results: The results indicate that dual pathology patients with Cluster C personality disorder do not differ from controls, and that the presence of dual pathology does not influence the updating domain of executive functioning. The findings were inconclusive with regard to dual pathology patients with Cluster B personality disorders. Whilst the various studies consistently show that these patients show worse performance than the control groups, here are contradictory results with regard to whether Cluster B personality disorders add more alterations in executive functioning to those that already appear in substance use disorder. Conclusions: The results suggest the need for further research that more adequately controls variables such as time in treatment, medication, and sample size, whilst there is also a need to employ longitudinal designs that include more patients from Clusters A and C.

中文翻译：

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共患物质使用和人格障碍患者的执行功能受损：系统评价

目的 本系统评价的目的是检查被诊断为人格障碍 (PD) 和物质使用障碍双重病理的患者执行功能受损的证据，并确定与单一诊断的患者相比是否存在差异。方法：进行了系统搜索，以确定使用对 PD 物质使用障碍双重病理患者执行功能测量的研究。选择了 16 项研究。结果：结果表明，C 类人格障碍的双重病理患者与对照组没有区别，双重病理的存在不影响执行功能的更新域。对于患有 B 类人格障碍的双重病理患者，研究结果尚无定论。虽然各种研究一致表明这些患者的表现比对照组差，但关于 B 类人格障碍是否会为已经出现物质使用障碍的患者增加更多的执行功能改变，这里有矛盾的结果。结论：结果表明需要进一步研究以更充分地控制诸如治疗时间、药物和样本量等变量，同时还需要采用纵向设计，包括更多来自聚类 A 和 C 的患者。