Assessment of the Relationship between Clinical Variants of Psoriasis and Killer Immunoglobulin-like Receptor (KIR) Genes: A Systematic Review with Meta-analysis,Immunological Investigations

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Assessment of the Relationship between Clinical Variants of Psoriasis and Killer Immunoglobulin-like Receptor (KIR) Genes: A Systematic Review with Meta-analysis
Immunological Investigations ( IF 2.8 ) Pub Date : 2020-10-29 , DOI: 10.1080/08820139.2020.1840582
José Macías-Barragán ₁ , Margarita Montoya-Buelna ₂ , Moisés Enciso-Vargas ₃ , Liliana Alvarado-Ruíz ₄ , Edén Oceguera-Contreras ₁ , Aracely Suggey Guerra-Renteria _{1,

4} , Omar Graciano-Machuca ₁

Affiliation

ABSTRACT

Background

Psoriasis (Ps) is an autoimmune dermatosis. Previous studies have shown an association between KIR genes and susceptibility to some clinical variants of Ps. Therefore, we conducted an exhaustive systematic review with meta-analysis to evaluate the relationship between KIR genes and susceptibility to clinical variants of Ps in the overall population and according to ethnicity.

Methods

According to PRISMA guidelines, we performed a systematic review through PubMed and Web of Science to identify relevant available scientific publications about KIR genes and Ps. The quality of the studies was evaluated using the Newcastle–Ottawa scale. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using random and fixed effect models for the analyzed genes. Heterogeneity was tested using Cochran’s Q-Statistic and I², and the risk of bias was tested using the Begg test and Egger linear regression.

Results

A total of 10 case-control studies were included, comprising a variable number of KIR typified genes and psoriasis vulgaris (PsV) as the main clinical variant studied. In the total pooled results, the KIR2DS1 gene (OR = 1.518, p = .010, 95%CI: 1.105 to 2.086) was related to higher susceptibility to PsV, while the KIR2DS4 (OR = 0.563, p = .005, 95%CI: 0.376 to 0.842) and KIR3DL1 (OR = 0.602, p = .040, 95%CI: 0.370 to 0.977) genes were related to protection against PsV.

Conclusion

This meta-analysis demonstrates that subjects that carry the KIR2DS1 gene could have a potential risk factor for the development of PsV. Conversely, KIR2DS4 and 3DL1 genes appear to confer protection against PsV.

中文翻译：

银屑病临床变异与杀伤性免疫球蛋白样受体 (KIR) 基因之间关系的评估：荟萃分析的系统评价

摘要

背景

银屑病 (Ps) 是一种自身免疫性皮肤病。先前的研究表明，KIR基因与对某些 Ps 临床变异的易感性之间存在关联。因此，我们通过荟萃分析进行了详尽的系统评价，以评估KIR基因与总体人群中 Ps 临床变异的易感性之间的关系以及根据种族。

方法

根据 PRISMA 指南，我们通过 PubMed 和 Web of Science 进行了系统审查，以确定有关KIR基因和 Ps 的相关可用科学出版物。使用纽卡斯尔-渥太华量表评估研究的质量。使用分析基因的随机和固定效应模型估计优势比 (OR) 和 95% 置信区间 (95% CI)。异质性使用 Cochran's Q -Statistic 和 I ²进行测试，偏倚风险使用 Begg 检验和 Egger 线性回归进行测试。

结果

共纳入 10 项病例对照研究，包括可变数量的KIR典型基因和作为研究的主要临床变异的寻常型银屑病 (PsV)。在总汇总结果中，KIR2DS1基因 (OR = 1.518, p = .010, 95%CI: 1.105 至 2.086) 与 PsV 的更高易感性相关，而KIR2DS4 (OR = 0.563, p = .005, 95% CI: 0.376 到 0.842) 和KIR3DL1 (OR = 0.602, p = .040, 95%CI: 0.370 到 0.977) 基因与对 PsV 的保护有关。