ABSTRACT

Introduction: Controlling the preventable infectious diseases is the main goal of vaccination. Among the vaccines, combined vaccines are of great importance for their social, public health, and economic values. It is stated that the combined vaccines are as efficient and safe as the monovalent vaccines. However, a concern has raised about the efficacy and safety of the combined vaccines due to the outbreaks of vaccine-preventable diseases and occurrence of serious adverse events.

Areas covered: A retrospective literature search was conducted in the Google Scholar and PubMed databases to evaluate the efficacy and safety of the combined vaccines from 1980 to 2020 using appropriate keywords.

Expert opinion: Several studies have shown efficacy and safety issues related to the combined vaccines. Different factors contribute to the inefficacy and lack of safety in the vaccines including formulation problems, limited data in the pre-licensure studies and challenges related to imperfection of the post-licensure surveillance systems. For surmounting the mentioned obstacles, there is a need to provide new formulations of the vaccines, revise the vaccines҆ safety and efficacy acceptance standards in the pre-licensure studies, improvement of post-licensure surveillance systems, and education of healthcare staff.

摘要

介绍

控制可预防的传染病是疫苗接种的主要目标。在这些疫苗中，组合疫苗对其社会，公共卫生和经济价值至关重要。据指出，组合疫苗与单价疫苗一样有效且安全。然而，由于疫苗可预防疾病的爆发和严重不良事件的发生，人们对联合疫苗的有效性和安全性提出了担忧。

覆盖区域

在Google Scholar和PubMed数据库中进行了回顾性文献检索，以使用适当的关键词评估1980年至2020年联合疫苗的疗效和安全性。

专家意见

多项研究显示了与联合疫苗相关的功效和安全性问题。造成疫苗效力低下和缺乏安全性的各种因素包括制剂问题，许可前研究中的数据有限，与许可后监测系统不完善有关的挑战，疫苗的生物学性质以及免疫应答的个体差异。为了克服上述障碍，需要提供新的疫苗制剂，修订许可前研究中疫苗的安全性和功效接受标准，改善许可后监测系统和医护人员的教育。