Abstract

Post-translational modifications (PTMs) play a pivotal role in expanding functional protein diversity. During viral infection, pathogen-associated molecular patterns derived from viruses are recognized by pattern recognition receptors present in the membrane surface and the cytoplasm of infected cells, which subsequently induces the antiviral innate immunity to protect the host from the invading viruses. Fatty acylation modification is identified as a post-translation lipid modification process. Mounting evidence is presented that lipid modification functions as a novel regulatory mechanism of antiviral innate immunity. In mammalian cells, DHHC (Asp-His-His-Cys) domain is indispensable for most of the palmitoylation modification, which belongs to fatty acylation. ZDHHC family proteins are composed of 23 members in human cells. In this review, we will summarize the recent findings of the regulatory mechanism of the palmitoylation in the process of host antiviral innate immunity against viruses.

摘要

翻译后修饰（PTM）在扩大功能性蛋白质多样性中起关键作用。在病毒感染期间，源自病毒的病原体相关分子模式被存在于被感染细胞的膜表面和细胞质中的模式识别受体所识别，随后可诱导抗病毒先天免疫力，从而保护宿主免受入侵病毒的侵害。脂肪酰化修饰被鉴定为翻译后脂质修饰过程。越来越多的证据表明，脂质修饰是抗病毒先天免疫的新型调节机制。在哺乳动物细胞中，DHHC（Asp-His-His-Cys）结构域对于大多数棕榈酰化修饰是必不可少的，属于脂肪酰化作用。ZDHHC家族蛋白由人类细胞中的23个成员组成。在这篇评论中