当前位置: X-MOL 学术J. Biochem. Mol. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Protective effects of natural compounds against oxidative stress in ischemic diseases and cancers via activating the Nrf2 signaling pathway: A mini review
Journal of Biochemical and Molecular Toxicology ( IF 3.6 ) Pub Date : 2020-10-28 , DOI: 10.1002/jbt.22658
Wenji Li 1, 2, 3 , Kai Sun 1, 2 , Fang Hu 1, 2 , Longfei Chen 4 , Xing Zhang 5 , Fuxing Wang 1, 2 , Bingchun Yan 1, 2, 3
Affiliation  

Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been seen in the pathological states of many disorders such as ischemic diseases and cancers. Many natural compounds (NCs) have long been recognized to ameliorate oxidative stress due to their inherent antioxidant activities. The modulation of oxidative stress by NCs via activating the Nrf2 signaling pathway is summarized in the review. Three NCs, ursolic acid, betulinic acid, and curcumin, and the mechanisms of their cytoprotective effects are investigated in myocardial ischemia, cerebral ischemia, skin cancer, and prostate cancer. To promote the therapeutic performance of NCs with poor water solubility, the formulation approach, such as the nano drug delivery system, is elaborated as well in this review.

中文翻译:

天然化合物通过激活Nrf2信号通路对缺血性疾病和癌症中氧化应激的保护作用:迷你综述

在许多疾病(例如缺血性疾病和癌症)的病理状态下,已经发现了氧化应激,即活性氧和抗氧化剂之间的不平衡。长期以来,由于其固有的抗氧化活性,许多天然化合物(NCs)可以缓解氧化应激。该综述总结了NCs通过激活Nrf2信号传导途径对氧化应激的调节作用。在心肌缺血,脑缺血,皮肤癌和前列腺癌中研究了三种NCs,熊果酸,桦木酸和姜黄素及其细胞保护作用的机制。为了提高水溶性差的NCs的治疗性能,在本综​​述中还详细阐述了诸如纳米药物递送系统之类的配制方法。
更新日期:2020-10-28
down
wechat
bug