This paper utilizes a combined approach of the convection‐diffusion theory and the moment analysis to conduct a comprehensive investigation of the solute dispersion under the influence of the interphase transport in finitely long inner coated microchannels. The present work has threefold novel contributions: (1) The 2D solute concentration contours in the stationary phase are calculated for the first time to facilitate the understanding the role of the interphase transport in the solute dispersion in the mobile phase. (2) The skewness of the elution curves is investigated to guide the control of solute band shape at the channel outlet. (3) The 2D diffusion‐convection theory and zero‐dimensional (0D) moment analysis complement each other to present a characterization of the solute dispersion behaviors more comprehensive than that by either of the two methods alone. Parametric studies are performed to clarify the effects of four major parameters related to the interphase transport (i.e., stationary phase Péclet number, interphase transport rate, partition coefficient, and stationary phase thickness) on the solute dispersion characteristics. The results from this study provide a straightforward understanding of the effects of interphase transport on the solute dispersion in finitely long microchannels and are of potential relevance to the design and operation of the microfluidics‐based analytical devices.

中文翻译：

---

具有相间传输的有限长度微通道中溶质分散的数值研究

本文采用对流扩散理论和矩分析相结合的方法，对有限长内涂层微通道中相间传输影响下的溶质扩散进行了综合研究。目前的工作有三个新的贡献：(1) 首次计算了固定相中的 2D 溶质浓度等值线，以促进理解相间传输在流动相中溶质分散中的作用。(2) 研究洗脱曲线的偏度以指导通道出口处溶质带形状的控制。(3) 2D 扩散对流理论和零维 (0D) 矩分析相辅相成，比单独使用两种方法中的任何一种都更全面地呈现溶质扩散行为的表征。进行参数研究以阐明与相间传输相关的四个主要参数（即固定相 Péclet 数、相间传输速率、分配系数和固定相厚度）对溶质分散特性的影响。这项研究的结果提供了对相间传输对有限长微通道中溶质分散的影响的直接理解，并且与基于微流体的分析装置的设计和操作具有潜在的相关性。进行参数研究以阐明与相间传输相关的四个主要参数（即固定相 Péclet 数、相间传输速率、分配系数和固定相厚度）对溶质分散特性的影响。这项研究的结果提供了对相间传输对有限长微通道中溶质分散的影响的直接理解，并且与基于微流体的分析装置的设计和操作具有潜在的相关性。进行参数研究以阐明与相间传输相关的四个主要参数（即固定相 Péclet 数、相间传输速率、分配系数和固定相厚度）对溶质分散特性的影响。这项研究的结果提供了对相间传输对有限长微通道中溶质分散的影响的直接理解，并且与基于微流体的分析装置的设计和操作具有潜在的相关性。