A double four component Azido‐Ugi reaction of isocyanide, TMSN₃, aldehyde, and 4,4′‐sulfonyldianiline with two amine functional groups in MeOH at 65°C has been described. The synthesis of pharmacologically and structurally interesting compounds with two 1,5‐disubstituted tetrazole rings via a reaction from available and inexpensive reagents under a convenient process and mild reaction conditions has been reported. Modifications in the structure of the reaction product could be followed by varying the aldehyde or isocyanide component. The products are new and were well described by Mass, ¹H NMR, and ¹³C NMR spectral studies.

中文翻译：

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通过双四组分叠氮基-Ugi反应合成双（1,5-二取代的四唑）

在65°C的甲醇中，已描述了异氰酸酯，TMSN ₃，醛和4,4'-磺酰基二苯胺与两个胺官能团的双四组分Azido-Ugi反应。据报道，在方便的方法和温和的反应条件下，通过可得的廉价试剂进行反应，可合成具有两个1,5-二取代的四唑环的药理和结构有趣的化合物。可以通过改变醛或异氰化物组分来改变反应产物的结构。产物是新产物，通过质量，¹ H NMR和¹³ C NMR光谱研究得到了很好的描述。