Black phosphorus nanosheet (BPNS) is a promising multifunctional material in the biomedical field with biodegradability and low side effects, however its features are always weakened severely owing to its poor stability. Here, a novel method is developed for improving the defect of BPNS based on the effective protection of poly(lactic‐co‐glycolic acid) (PLGA), which preserves the stable photothermal therapy (PTT) effect of BPNS and biodegradability of the material. Meanwhile, doxorubicin (DOX) is loaded on BPNS/PLGA to get BPNS/PLGA/DOX for further chemotherapy and preventing the recurrence of tumor after PTT. The presented combined therapeutic strategy exploits the strengths and improves the defects of BPNS, thus developing an efficient and safe nanoagent for cancer therapy, which affords and reveals the great potential of BPNS in nanomedicine.

中文翻译：

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可生物降解的基于黑磷-纳米片的纳米剂，用于增强化学光热疗法

黑磷纳米片（BPNS）在生物医学领域是一种很有前途的多功能材料，具有生物可降解性和低副作用，但是由于其稳定性差，其功能始终会受到严重削弱。在此，一种新型的方法用于改善BPNS的基于聚有效地保护了缺陷显影（乳酸-共-乙醇酸（PLGA），保留了BPNS的稳定光热疗法（PTT）效果和材料的生物降解性。同时，将阿霉素（DOX）加载到BPNS / PLGA上以获得BPNS / PLGA / DOX进行进一步的化疗，并防止PTT后肿瘤复发。提出的联合治疗策略利用了BPNS的优势并改善了BPNS的缺陷，从而开发了一种有效且安全的用于癌症治疗的纳米剂，这提供并揭示了BPNS在纳米医学中的巨大潜力。