Proteins are an essential part of organisms and play a very important role in life activities. Molecular imprinting technology (MIT) can prepare functional materials with specific identification abilities. In recent years, various molecularly imprinted materials have been widely used in the fields of solid‐phase extraction, bionic sensing, and on‐line analysis. Due to the limit of the properties of protein macromolecules, the development of MIT for protein molecules is relatively slow. With the continuous deepening on the research of nanomaterials and surface molecular imprinting technology, a large numbers of interesting and successful strategies appear on imprinted protein. Some surface protein imprinting materials with excellent properties and unique functions are applied in proteomics, biological imaging, medical diagnosis, and other fields, showing great potential application value. This paper summarizes the latest preparation and analysis strategies of surface protein imprinting based on nanomaterials, introduces medical application of protein imprinting materials in sample separation and purification, proteomics, biomedical and other aspects in recent years, and looks forward to the development opportunities and challenges in protein imprinting field.

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基于纳米材料的表面蛋白印迹聚合物：合成和医学应用

蛋白质是有机体的重要组成部分，在生命活动中起着非常重要的作用。分子印迹技术（MIT）可以制备具有特定识别能力的功能材料。近年来，各种分子印迹材料已广泛用于固相萃取，仿生传感和在线分析领域。由于蛋白质大分子特性的限制，用于蛋白质分子的MIT的发展相对缓慢。随着对纳米材料和表面分子印迹技术研究的不断深入，印迹蛋白上出现了大量有趣而成功的策略。一些具有优异性能和独特功能的表面蛋白质印迹材料被用于蛋白质组学，生物成像，医学诊断等领域，显示出巨大的潜在应用价值。本文总结了基于纳米材料的表面蛋白质印迹的最新制备和分析策略，介绍了蛋白质印迹材料在样品分离和纯化，蛋白质组学，生物医学等方面的医学应用，并展望了其发展机遇和挑战。蛋白质印迹领域。