Several published reports have described a possible association between Guillain‐Barré syndrome (GBS) and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. This systematic review aimed to summarize and meta‐analyze the salient features and prognosis of SARS‐CoV‐2‐associated GBS. We searched the PubMed (Medline), Web of Science and Cochrane databases for articles published between 01 January 2020 and 05 August 2020 using SARS‐CoV‐2 and GBS‐related keywords. Data on sociodemographic characteristics, antecedent symptoms, clinical, serological and electrophysiological features, and hospital outcomes were recorded. We included 45 articles from 16 countries reporting 61 patients with SARS‐CoV‐2‐associated GBS. Most (97.7%) articles were from high‐ and upper‐middle‐income countries. Forty‐two (68.9%) of the patients were male; median (interquartile range) age was 57 (49‐70) years. Reverse transcriptase polymerase chain reaction for SARS‐CoV‐2 was positive in 90.2% of patients. One report of SARS‐CoV‐2‐associated familial GBS was found which affected a father and daughter of a family. Albuminocytological dissociation in cerebrospinal fluid was found in 80.8% of patients. The majority of patients (75.5%) had a demyelinating subtype of GBS. Intravenous immunoglobulin and plasmapheresis were given to 92.7% and 7.3% of patients, respectively. Around two‐thirds (65.3%) of patients had a good outcome (GBS‐disability score ≤ 2) on discharge from hospital. Two patients died in hospital. SARS‐CoV‐2‐associated GBS mostly resembles the classical presentations of GBS that respond to standard treatments. Extensive surveillance is required in low‐ and lower‐middle‐income countries to identify and report similar cases/series. Further large‐scale case‐control studies are warranted to strengthen the current evidence. PROSPERO Registration Number CRD42020201673.

中文翻译：

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与SARS-CoV-2感染相关的Guillain-Barré综合征：系统评价和个体参与者数据荟萃分析

几篇已发表的报告描述了格林-巴利综合征（GBS）与严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）感染之间的可能联系。本系统综述旨在总结和荟萃SARS-CoV-2相关GBS的显着特征和预后。我们使用SARS‐CoV‐2和GBS相关关键字在PubMed（Medline），Web of Science和Cochrane数据库中搜索了2020年1月1日至2020年8月5日之间发布的文章。记录有关社会人口学特征，先兆症状，临床，血清学和电生理特征以及医院预后的数据。我们纳入了来自16个国家/地区的45篇文章，报道了61例SARS-CoV-2相关性GBS患者。大多数文章（97.7％）来自高收入和中上收入国家。患者中有四十二名（68.9％）为男性；中位（四分位间距）年龄为57（49-70）岁。90.2％的患者的SARS-CoV-2逆转录酶聚合酶链反应呈阳性。发现了一份与SARS-CoV-2相关的家族性GBS的报告，该报告影响了一个家庭的父母。在80.8％的患者中发现了脑脊液中的白细胞分离。大多数患者（75.5％）患有GBS脱髓鞘亚型。分别给92.7％和7.3％的患者静脉注射免疫球蛋白和血浆清除。大约三分之二（65.3％）的患者出院时有良好的预后（GBS残疾评分≤2）。两名患者在医院死亡。与SARS-CoV-2相关的GBS大多类似于对标准疗法有反应的GBS的经典表现。低收入和中低收入国家需要进行广泛的监视，以识别和报告类似的病例/系列。有必要进行进一步的大规模病例对照研究，以加强现有证据。PROSPERO注册号CRD42020201673。