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The key role of mass spectrometry in comprehensive research on new psychoactive substances
Journal of Mass Spectrometry ( IF 2.3 ) Pub Date : 2020-10-29 , DOI: 10.1002/jms.4673
David Fabregat-Safont 1 , Juan V Sancho 1 , Félix Hernández 1 , María Ibáñez 1
Affiliation  

New psychoactive substances (NPS) are a wide group of compounds that try to mimic the effects produced by the ‘classical’ illicit drugs, including cannabis (synthetic cannabinoids), cocaine and amphetamines (synthetic cathinones) or heroin (synthetic opioids), and which health effects are still unknown for most of them. Nowadays, more than 700 compounds are being monitored by official organisms, some of which have been recently identified in seizures and/or intoxication cases. Toxicological analysis plays a pivotal role in NPS research. A comprehensive investigation on NPS, from the first identification of a novel substance until its detection in drug users to help in diagnostics and medical treatment, requires the use of a wide variety of instruments and analytical strategies. This paper illustrates the key role of mass spectrometry (MS) along a comprehensive investigation on NPS. The synthetic cannabinoid XLR-11 and the synthetic cathinone 5-PPDi have been chosen as representative substances of the most consumed NPS families. Moreover, both compounds have been investigated at our laboratory in different stages of the three-step strategy considered in this article. The initial identification and characterisation of the compound in consumption products, the first reported metabolic pathway and the development of analytical methodologies for its determination (and/or their metabolites) in different toxicological samples are described. The analytical strategies and MS instruments are briefly discussed to show the reader the possibilities that MS instrumentation offer to analytical scientists. This publication aims to be a starting point for those interested on the NPS research field from an analytical chemistry point of view.

中文翻译:

质谱在新型精神活性物质综合研究中的关键作用

新型精神活性物质 (NPS) 是一组广泛的化合物,它们试图模仿“经典”非法药物产生的效果,包括大麻(合成大麻素)、可卡因和安非他明(合成卡西酮)或海洛因(合成阿片类药物)。他们中的大多数人的健康影响仍然未知。如今,官方生物正在监测 700 多种化合物,其中一些最近在癫痫发作和/或中毒病例中被发现。毒理学分析在 NPS 研究中起着举足轻重的作用。对 NPS 的全面调查,从首次鉴定一种新物质到在吸毒者中检测到它以帮助诊断和医疗,需要使用各种仪器和分析策略。本文阐述了质谱 (MS) 在 NPS 综合研究中的关键作用。合成大麻素 XLR-11 和合成卡西酮 5-PPDi 已被选为消费最多的 NPS 家族的代表物质。此外,我们实验室已经在本文考虑的三步策略的不同阶段对这两种化合物进行了研究。描述了消费产品中化合物的初步鉴定和表征、首次报道的代谢途径以及在不同毒理学样品中测定其(和/或其代谢物)的分析方法的发展。简要讨论了分析策略和 MS 仪器,以向读者展示 MS 仪器为分析科学家提供的可能性。
更新日期:2020-10-29
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