This study mainly discussed the effect of fermented Huyou juice (FHJ) on modulating the intestinal microbiota of human, and anti‐obesity mechanisms. Through the way of metagenomics, the effect of FHJ on gut flora has been summarized with a mice model of obesity induced by human flora‐associated (HFA) high‐fat diet. The results showed that the FHJ ameliorated the gut dysbiosis caused by obesity. When receiving FHJ treatment, a dramatic decrease in Firmicutes/Bacteroidetes occurred. What’s more, having experienced 8 weeks of FHJ intervention, KEGG pathways of two‐component system, ATP‐binding cassette (ABC) transporters, and biosynthesis of amino acids made the most differentially expressed genes more abundant, the unigene numbers are 16781,480, and 1,221, respectively. Our results may be of great significance to the use of FHJ which serves as a functional fermented beverage product with the underlying effect of treating the obesity induced by high‐fat diet. The FHJ helps to improve the host health by regulating the intestinal flora and affecting some metabolic pathways.

中文翻译：

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高脂饮食诱导的肥胖小鼠模型中发酵胡柚汁对肠道菌群的影响

这项研究主要讨论了发酵胡柚汁（FHJ）对调节人体肠道菌群的影响以及抗肥胖机制。通过宏基因组学的方法，已将FHJ对肠道菌群的影响与人类菌群相关（HFA）高脂饮食诱导的肥胖小鼠模型进行了总结。结果表明，FHJ改善了肥胖引起的肠道营养不良。当接受FHJ治疗时，硬毛虫/拟杆菌的数量急剧减少。此外，经过8周的FHJ干预，两组分系统的KEGG途径，ATP结合盒（ABC）转运蛋白和氨基酸的生物合成，使得最差异表达的基因更加丰富，单基因数量为16781,480，和1,221。我们的结果可能对FHJ的使用具有重要意义，FHJ用作功能性发酵饮料产品，具有治疗高脂饮食引起的肥胖症的潜在作用。FHJ通过调节肠道菌群并影响某些代谢途径来帮助改善宿主健康。