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Correlation of skin prick testing to environmental allergens
Annals of Allergy, Asthma & Immunology ( IF 5.9 ) Pub Date : 2020-10-26 , DOI: 10.1016/j.anai.2020.10.010
Lillian Grobman , Jessica Kitsen , Diba Mortazavi , Bob Geng

Background

To diagnose and adequately treat allergies, identification of sensitizing allergens is crucial. Skin prick or serum immunoglobulin E testing determines sensitization to potential allergens. Consensus varies regarding degree of cross-reactivity between aeroallergens.

Objective

To quantify correlations between aeroallergen skin prick test results.

Methods

A total of 11,832 patients’ quantitative skin prick test results and basic characteristics were obtained from a tertiary academic center’s electronic medical record and deidentified. Data were analyzed using Spearman’s rank correlation coefficients to detect nonlinear associations between wheal sizes of skin prick test results.

Results

The highest correlation among grasses was 0.903 (fescue and red top). Of note, 13 more grass pairs had correlation more than 0.8, and 19 had correlation between 0.7 and 0.8. The Northern grass comparative results are from a satellite clinic that tested more grasses than the main clinic, in which only Kentucky blue and Bermuda were tested (correlation 0.768; n = 9348). Highest correlation among weeds was 0.74 (lambs quarter and pigweed). In addition, 6 more weed pairs had correlation more than 0.7. Highest correlation among trees was 0.724 (palm and alder) and 6 more tree pairs had correlation more than 0.7. Highest correlation among molds was 0.711 (Helminthosporium and Epicoccum). Dust mite correlation between Dermatophagoides farinae and Dermatophagoides pteronyssinus was 0.848 (n = 10,022).

Conclusion

This study confirmed the expected high degrees of correlation not only between skin prick test results of related environmental allergens but also between less closely related Northern grasses and Bermuda grass. This has implications for simplification of testing and immunotherapy protocols in the future.



中文翻译:

皮肤点刺测试与环境过敏原的相关性

背景

为了诊断和充分治疗过敏,鉴定致敏过敏原至关重要。皮肤刺或血清免疫球蛋白E检测可确定对潜在过敏原的敏感性。空气过敏原之间的交叉反应程度存在共识。

客观的

为了量化空气过敏原皮肤点刺试验结果之间的相关性。

方法

从一所大学学术中心的电子病历中获得了总计11,832例患者的定量皮肤点刺测试结果和基本特征,并对其进行了身份识别。使用Spearman秩相关系数分析数据,以检测皮肤点刺测试结果的风团大小之间的非线性关联。

结果

草之间的最高相关性是0.903(羊茅和红顶)。值得注意的是,还有13对草的相关性大于0.8,而19对草的相关性在0.7和0.8之间。北部草的比较结果来自卫星诊所,该卫星诊所的草比主要诊所的草要多,在主要诊所中仅对肯塔基州的蓝和百慕大进行了测试(相关系数0.768; n = 9348)。杂草之间的最高相关性是0.74(羊羔季和杂草)。此外,还有6对杂草对的相关性大于0.7。树木之间的最高相关度为0.724(棕榈和al木),另外6对树的相关度超过0.7。霉菌之间的最高相关性是0.711(蠕虫Epicoccum)。与尘螨相关性粉尘螨蕨类植物皮肤癣菌为0.848(n = 10022)。

结论

这项研究证实了预期的高度相关性,不仅在相关环境过敏原的皮肤点刺试验结果之间,而且在不太紧密相关的北方草和百慕大草之间也是如此。这对将来简化测试和免疫疗法方案具有影响。

更新日期:2020-10-26
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