Neospora infections due to Neospora caninum and N. hughesi are prevalent among equids of the world. The disease may affect reproductive and neurological consequences. The present systematic review and meta-analysis was performed to evaluate the global Neospora seroprevalence among horses and donkeys. A number of 57 out of 1575 total retrieved studies were included by searching the PubMed, Scopus, Science Direct, Web of Science and ProQuest. A total of 25,783 horses and 4377 donkeys were examined serologically, yielding a weighted seroprevalence of 13.46 % (95 % CI: 10.26 %–17.42 %) globally. Subgroup analysis revealed that there were statistically significant differences in the overall prevalence of Neospora spp. in the examined animals according to year, continent, WHO region, country, host, and diagnostic method. Age and sex in horses as well as sex in donkeys were significantly associated with the Neospora seroprevalence (P < 0.001). Our findings showed a relatively high exposure to Neospora spp. in horses and donkeys worldwide. Considering the possible economic impact, as well as the importance in animal health, more studies are needed to clarify the species causing equine neosporosis, correlate serological findings with clinical outcomes and assess the risk factors, in order to define adequate prevention and control strategies.

犬新孢子虫和休斯猪笼草引起的新孢子虫感染在世界上的动物中十分普遍。该疾病可能影响生殖和神经系统后果。目前进行了系统的审查和荟萃分析，以评估马和驴之间的全球新孢子虫血清阳性率。通过搜索PubMed，Scopus，Science Direct，Web of Science和ProQuest，总共检索了1575个研究中的57个。总共对25,783匹马和4377头驴进行了血清学检查，全球范围内的加权血清阳性率为13.46％（95％CI：10.26％–17.42％）。亚组分析显示，新孢子虫的总体患病率存在​​统计学差异spp。根据年份，大洲，WHO地区，国家/地区，宿主和诊断方法对动物进行检测。马的年龄和性别以及驴的性别与新孢子虫的血清阳性率显着相关（P <0.001）。我们的发现表明，新孢子虫属的暴露量相对较高。在世界各地的马和驴中。考虑到可能的经济影响以及在动物健康中的重要性，需要进行更多的研究以阐明引起马新孢子虫病的物种，将血清学发现与临床结果相关联，并评估风险因素，以便定义适当的预防和控制策略。