Dendritic cells (DCs) have been classified into distinct subsets based on phenotype and ontogeny. In the past few years, high throughput single-cell approaches have revealed further heterogeneity of human DCs, in particular at the transcriptomic level. Herein examined, are recent studies describing new human DC populations based on single-cell RNA-seq analysis, and a unified view of these emerging DC populations is presented. Also assessed are the features that define bona fide DC lineages, as opposed to cell states of the same lineage. Finally, where these newly described DC populations fit in the ontogeny-based classification of human DCs is examined.

中文翻译：

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解码人类树突状细胞亚群的异质性

树突状细胞（DCs）已根据表型和个体发育分为不同的亚组。在过去的几年中，高通量单细胞方法揭示了人类DC的进一步异质性，尤其是在转录组水平上。本文研究了基于单细胞RNA-seq分析描述新人类DC种群的最新研究，并给出了这些新兴DC种群的统一视图。还评估了定义真实DC谱系的功能，而不是同一谱系的细胞状态。最后，检查了这些新描述的DC种群适合于基于个体的人类DC分类的地方。