In recent years, dynamic covalent chemistry (DCC) has seen the synthesis of increasingly complex cyclooligomers, polymers, and diverse compound libraries. The reversible formation of covalent bonds characteristic of DCC reactions favors thermodynamic product distributions for simple unitopic reactions; however, kinetic effects are increasingly influential in reactions of multitopic precursors. In this review, we explore the interplay between thermodynamic and kinetic considerations when planning a DCC synthesis. Computational models, typically based on reaction thermodynamics, have aided in predicting DCC reaction outcomes with moderate success. A clear direction for the field is to develop more robust computational tools informed by thermodynamic and kinetic driving forces that can predict product distributions in DCC reactions.

近年来，动态共价化学（DCC）已看到越来越复杂的环寡聚物，聚合物和各种化合物库的合成。DCC反应特征性共价键的可逆形成有利于简单单位反应的热力学产物分布；然而，动力学效应对多主题前体的反应越来越有影响。在这篇综述中，我们在计划DCC合成时探索了热力学和动力学考虑因素之间的相互作用。通常基于反应热力学的计算模型有助于成功预测DCC反应结果。该领域的明确方向是开发更强大的计算工具，该工具借助热力学和动力学驱动力来预测DCC反应中的产物分布。