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An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2
Trends in Chemistry ( IF 15.7 ) Pub Date : 2020-10-23 , DOI: 10.1016/j.trechm.2020.10.004
Lide Cha , Wei-chen Chang

A novel strategy to introduce C-isotopes at the carboxylate group has been discovered. Through ‘simple’ CO2 exchange under mild conditions, the C-isotope can be incorporated effectively and has been demonstrated in a variety of biologically important molecules. Also, this methodology is used to install a C–C bond when alternative electrophiles are employed.



中文翻译:

通过简单交换CO 2引入碳同位素的有效策略

已经发现了在羧酸酯基团上引入C-同位素的新策略。通过在温和条件下进行“简单” CO 2交换,可以有效地掺入C同位素,并已在多种生物学上重要的分子中得到证明。同样,当使用其他亲电试剂时,该方法学也用于安装C–C键。

更新日期:2020-11-26
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