Research question

What is the impact of low body mass index (BMI) on live birth rates and obstetric outcomes in infertile women treated with IVF and fresh embryo transfer?

Design

This was a retrospective cohort study of infertile patients in an academic hospital setting who underwent their first oocyte retrieval with planned autologous fresh embryo transfer between 1 January 2012 and 31 December 2018. The primary study outcome was live birth rate. Secondary outcomes were IVF treatment and delivery outcomes. Underweight patients were stratified into a significantly underweight group (body mass index [BMI] <17.5 kg/m²) and a mildly underweight group (BMI 17.5–18.49 kg/m²), and were compared with a normal-weight group (BMI 18.5–24.9 kg/m²).

Results

A total of 5229 patients were included (significantly underweight, 76; mildly underweight, 231; normal weight, 4922), resulting in 4798 embryo transfers. After oocyte retrieval, there were no significant differences between groups for total oocytes, mature oocyte yield and number of supernumerary blastocysts cryopreserved. Among women who had an embryo transfer, there were no significant differences in the live birth rates in significantly (31.0%, odds ratio [OR] 0.67, confidence interval [0.95, CI] 0.40–1.13) and mildly (37.7%, OR 0.95, CI 0.73–1.33) underweight patients compared with normal-weight patients (35.9%). Additionally, there were no statistically significant increased risks of preterm delivery, Caesarean delivery or a low birthweight (<2500 g) neonate.

Conclusions

Mildly and significantly underweight infertile women have similar pregnancy and live birth rates to normal-weight patients after IVF treatment. In addition, underweight patients do not have an increased risk of preterm delivery (<37 weeks), Caesarean delivery or a low birthweight neonate.

中文翻译：

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接受试管婴儿的轻度和显着体重不足女性的生殖和产科结果

研究问题

低体重指数 (BMI) 对接受试管婴儿和新鲜胚胎移植治疗的不孕妇女的活产率和产科结果有何影响？

设计

这是一项回顾性队列研究，对象是学术医院环境中的不育患者，他们在 2012 年 1 月 1 日至 2018 年 12 月 31 日期间接受了首次取卵并计划进行自体新鲜胚胎移植。主要研究结果是活产率。次要结果是试管婴儿治疗和分娩结果。体重不足的患者被分为显着体重不足组（体重指数 [BMI] <17.5 kg/m ²）和轻度体重不足组（BMI 17.5–18.49 kg/m ²），并与正常体重组（BMI ）进行比较18.5–24.9 kg/m ² )。

结果

总共包括 5229 名患者（显着体重不足，76 人；轻度体重不足，231 人；正常体重，4922 人），共进行了 4798 次胚胎移植。取卵后，各组之间在总卵母细胞、成熟卵母细胞产量和冷冻保存的多余囊胚数量方面没有显着差异。在接受胚胎移植的女性中，活产率在显着（31.0%，优势比 [OR] 0.67，置信区间 [0.95，CI] 0.40–1.13）和轻度（37.7%，OR 0.95）方面没有显着差异, CI 0.73–1.33) 体重不足的患者与体重正常的患者 (35.9%) 相比。此外，早产、剖腹产或低出生体重 (<2500 g) 新生儿的风险在统计学上没有显着增加。

结论

轻度和显着体重不足的不孕女性在接受试管婴儿治疗后与正常体重患者的妊娠率和活产率相似。此外，体重不足的患者不会增加早产（<37 周）、剖腹产或低出生体重新生儿的风险。