Although light emitting diodes (LEDs) are widely used in our daily lives, there is little research regarding LED light’'s po.ssible effects on biological functions. We used a zebrafish animal model to investigate the long-term effects of white, blue and red LED lights on cognitive learning and memory recall. Our data suggest that these treatments had not only an impact on learning but also surprisingly long-lasting effects, particularly with regard to individuals treated with red light. The qPCR results revealed that the expression levels of trpm4, trpa1b, grin2aa and dlg4 in the skin were increased after monochromatic light treatment. Furthermore, the up-regulation of trpm4 in the brain may correlate to enhanced learning and memory following red-light treatment. Our results identify a light-based stimulation system for enhancing zebrafish learning, which has the potential to provide important insights into the relationship between LED lighting and animal behaviour.

尽管发光二极管（LED）在我们的日常生活中被广泛使用，但是关于LED灯对生物功能的可能影响的研究很少。我们使用斑马鱼动物模型研究了白色，蓝色和红色LED灯对认知学习和记忆记忆的长期影响。我们的数据表明，这些治疗方法不仅对学习有影响，而且还具有令人惊讶的持久效果，尤其是对于红光治疗的患者。qPCR结果表明，单色光处理后，皮肤中trpm4，trpa1b，grin2aa和dlg4的表达水平增加。此外，trpm4的上调红光治疗后，大脑中的钙可能与增强的学习和记忆有关。我们的结果确定了一种用于增强斑马鱼学习的基于光的刺激系统，该系统有可能为LED照明与动物行为之间的关系提供重要见解。