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Flow physics of normal and abnormal bioprosthetic aortic valves
International Journal of Heat and Fluid Flow ( IF 2.6 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.ijheatfluidflow.2020.108740 Jung-Hee Seo , Chi Zhu , Jon Resar , Rajat Mittal
International Journal of Heat and Fluid Flow ( IF 2.6 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.ijheatfluidflow.2020.108740 Jung-Hee Seo , Chi Zhu , Jon Resar , Rajat Mittal
Abstract Flow physics of transvalvular flows in the aorta with bioprosthetic valves are investigated using computational modelling. For the efficient simulations of flow-structure-interaction in transvalvular flows, a simplified, reduced degree of freedom valve model is employed with a sharp interface immersed boundary based incompressible flow solver. Simulations are performed for normal as well as abnormal valves with reduced leaflet motion that models the effect of early leaflet thrombosis. The structure of the aortic jet and the hemodynamic stresses on the aortic wall are analysed to understand the hemodynamic impacts and possible long-term clinical implications of sub-clinical, reduced leaflet motion. The simulation results have shown that the reduced leaflet motion tilts the direction of aortic jet and generates stronger flow separation and re-attachment on the aortic wall downstream from the reduced motion leaflets. The modified flow pattern increases the wall pressure fluctuation and average wall shear stress on the downstream aortic wall, and results in the asymmetric oscillatory shear index distributions, which may have long-term clinical implications such as aortic wall damage and remodelling.
中文翻译:
正常和异常生物人工主动脉瓣的流动物理学
摘要 使用计算模型研究了带有生物人工瓣膜的主动脉中跨瓣血流的流动物理学。为了有效模拟跨瓣流中的流动-结构-相互作用,采用了一种简化的、降低自由度的阀门模型,该模型具有基于浸没边界的尖锐界面不可压缩流动求解器。对正常和异常瓣膜进行模拟,其中小叶运动减少,模拟早期小叶血栓形成的影响。分析主动脉射流的结构和主动脉壁上的血流动力学应力,以了解亚临床、减少的小叶运动对血流动力学的影响和可能的长期临床意义。模拟结果表明,减少的小叶运动会倾斜主动脉射流的方向,并在减少运动的小叶下游的主动脉壁上产生更强的流动分离和重新附着。修改后的流动模式增加了下游主动脉壁的壁压波动和平均壁剪切应力,并导致不对称的振荡剪切指数分布,这可能具有长期的临床意义,如主动脉壁损伤和重塑。
更新日期:2020-12-01
中文翻译:
正常和异常生物人工主动脉瓣的流动物理学
摘要 使用计算模型研究了带有生物人工瓣膜的主动脉中跨瓣血流的流动物理学。为了有效模拟跨瓣流中的流动-结构-相互作用,采用了一种简化的、降低自由度的阀门模型,该模型具有基于浸没边界的尖锐界面不可压缩流动求解器。对正常和异常瓣膜进行模拟,其中小叶运动减少,模拟早期小叶血栓形成的影响。分析主动脉射流的结构和主动脉壁上的血流动力学应力,以了解亚临床、减少的小叶运动对血流动力学的影响和可能的长期临床意义。模拟结果表明,减少的小叶运动会倾斜主动脉射流的方向,并在减少运动的小叶下游的主动脉壁上产生更强的流动分离和重新附着。修改后的流动模式增加了下游主动脉壁的壁压波动和平均壁剪切应力,并导致不对称的振荡剪切指数分布,这可能具有长期的临床意义,如主动脉壁损伤和重塑。