To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely available at pHLA3D (www.phla3d.com.br) for immunologists and other researchers working with HLA molecules.

为了提高 HLA 分子的三维 (3D) 结构的可用性，我们创建了 pHLA3D 数据库。在第一个版本中，我们建模并发表了来自HLA-A、HLA-B和HLA-C位点的 HLA I 类分子的 106 个 3D 结构。本文介绍了该数据库的更新，提供了更多 127 个 HLA II 类分子（41 个 DR、42 个 DQ 和 44 个 DP）的 3D 结构，通过使用 MODELLER 和 SWISS-MODEL 的同源性建模进行预测。这些 HLA II 类分子的新 3D 结构现在可以在 pHLA3D (www.phla3d.com.br) 免费获得，供免疫学家和其他研究 HLA 分子的研究人员使用。