The extensive allelic variability observed in several genes related to the immune response and its significance in different areas including transplantation, disease association studies, diversity in human populations, among many others, has led the scientific community to analyse these variants among individuals. Serving as an electronic data warehouse, the Allele Frequency Net Database (AFND, http://www.allelefrequencies.net) contains data on the frequency of immune related genes and their corresponding alleles from more than 1700 worldwide population samples covering more than ten million unrelated individuals. The collection of population data sets available in AFND encompasses different polymorphic regions including the highly-polymorphic human leukocyte antigen (HLA) system for which more than 1200 populations are available. In this article, we provide an insight of the high diversity found in the HLA region by examining population data sets stored in AFND, as well as a description of the available data sets for further analyses.

在与免疫反应相关的几个基因中观察到的广泛的等位基因变异及其在不同领域的重要性，包括移植、疾病关联研究、人群多样性等，促使科学界分析个体之间的这些变异。作为一个电子数据仓库，等位基因频率网络数据库（AFND，http://www.allelefrequencies.net）包含免疫相关基因及其相应等位基因频率的数据，这些数据来自全球 1700 多个人口样本，覆盖超过一千万无关的个人。AFND 中可用的人口数据集包括不同的多态性区域，包括高多态性人类白细胞抗原 (HLA) 系统，可提供 1200 多个人口。在这篇文章中，