Background

The incidence of combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma (cHCC-ICC) is relatively low, and the knowledge about the prognosis of cHCC-ICC remains obscure. In the study, we aimed to screen existing primary liver cancer staging systems and shed light on the prognosis and risk factors for cHCC-ICC.

Methods

We retrospectively reviewed 206 cHCC-ICC patients who received curative surgical resection from April 1999 to March 2017. The correlation of survival measures with the histological types or with tumor staging systems was determined and predictive values of tumor staging systems with cHCC-ICC prognosis were compared.

Results

The histological type was not associated with overall survival (OS) (P = 0.338) or disease-free survival (DFS) (P = 0.843) of patients after curative surgical resection. BCLC, TNM for HCC, and TNM for ICC stages correlated with both OS and DFS in cHCC-ICC (all P < 0.05). The predictive values of TNM for HCC and TNM for ICC stages were similar in terms of predicting postoperative OS (P = 0.798) and DFS (P = 0.191) in cHCC-ICC. TNM for HCC was superior to BCLC for predicting postoperative OS (P = 0.022) in cHCC-ICC.

Conclusion

The TNM for HCC staging system should be prioritized for clinical applications in predicting cHCC-ICC prognosis.

中文翻译：

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现有的原发性肝癌分期系统是否适用于合并肝细胞癌-肝内胆管癌？

背景

合并肝细胞癌-肝内胆管癌（cHCC-ICC）的发生率相对较低，关于cHCC-ICC预后的知识仍不清楚。在这项研究中，我们旨在筛选现有的原发性肝癌分期系统，并阐明 cHCC-ICC 的预后和危险因素。

方法

我们回顾性回顾了 1999 年 4 月至 2017 年 3 月接受根治性手术切除的 206 例 cHCC-ICC 患者。 确定生存测量与组织学类型或肿瘤分期系统的相关性，并比较肿瘤分期系统与 cHCC-ICC 预后的预测值.

结果

组织学类型与 治愈性手术切除后患者的总生存期（OS）（P  =0.338）或无病生存期（DFS）（P =0.843）无关。BCLC、HCC 的 TNM 和 ICC 分期的 TNM 与 cHCC-ICC 的 OS 和 DFS 相关（所有P  < 0.05）。在预测 cHCC-ICC 的术后 OS ( P  = 0.798) 和 DFS ( P = 0.191)方面，TNM 对 HCC 和 TNM 对 ICC 分期的预测值相似。在预测 cHCC-ICC术后 OS 方面，HCC 的 TNM 优于 BCLC（P = 0.022）。

结论

HCC 分期系统的 TNM 应优先用于预测 cHCC-ICC 预后的临床应用。