Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-10-24 , DOI: 10.1016/j.etap.2020.103519 Ángeles C. Ochoa-Martínez , Yesenia Araiza-Gamboa , José A. Varela-Silva , Sandra T. Orta-García , Leticia Carrizales-Yáñez , Iván N. Pérez-Maldonado
Cardiovascular diseases (CVDs) are the primary cause of death worldwide. However, little is known about how the interaction between risk factors affects CVDs. Therefore, the aim of this study was to evaluate the effect of the gene-environment interaction (arsenic exposure x PON1 Q192R polymorphism) on serum levels of CVDs biomarkers in Mexican women. Urinary arsenic levels (UAs) ranged from 5.50–145 μg/g creatinine. The allele frequency was 0.38 and 0.62 for the Q and R alleles, respectively. Moreover, significant associations (p<0.05) were detected between UAs and CVDs biomarkers (ADMA, FABP4, and miR-155). Comparable data were found when CVDs biomarkers were evaluated through PON1 genotype, significant (p<0.05) higher serum concentrations of CVDs biomarkers were identified in R allele carriers compared to levels found in Q allele carriers. Besides, a gene-environment interaction was documented. The results of this study we believe should be of significant interest to regulatory authorities worldwide.
中文翻译:
基因-环境相互作用(砷暴露-PON1 Q192R多态性)对墨西哥人群心血管疾病生物标志物的影响
心血管疾病(CVD)是全球范围内的主要死亡原因。但是,关于危险因素之间的相互作用如何影响CVD的了解甚少。因此,本研究的目的是评估基因-环境相互作用(砷暴露x PON1 Q192R多态性)对墨西哥女性血清CVDs生物标志物水平的影响。尿砷水平(UAs)为5.50–145μg/ g肌酐。Q和R等位基因的等位基因频率分别为0.38和0.62。此外,在UAs和CVDs生物标志物(ADMA,FABP4和miR-155)之间检测到显着关联(p <0.05)。通过PON1基因型评估CVD生物标志物时发现了可比较的数据,与Q等位基因载体中发现的水平相比,在R等位基因载体中发现了显着(p <0.05)较高的CVDs生物标志物血清浓度。此外,还记录了基因与环境的相互作用。我们相信这项研究的结果应该引起全球监管机构的极大关注。