Pancreatic cancer (PC) is one the deadliest cancers worldwide. It is characterized by elevated mortality rates because of the lack of effective diagnostic methods, the dense stroma that shields the tumor from effective drug penetration, and the emergence of chemoresistance. Recent research has elucidated the role of PC-derived exosomes in driving and fueling PC progression, metastasis, and chemoresistance by transporting key molecules from tumor cells to recipient cells in the tumor microenvironment (TME). In this review, we delineate some of the key exosomal molecules involved in immune suppression and reprogramming of the TME, the establishment of metastatic niches, and drug resistance. We also explore the potential of exosomes as both diagnostic tools for early PC detection and management and as therapeutic targets.

胰腺癌 (PC) 是全球最致命的癌症之一。它的特点是由于缺乏有效的诊断方法导致死亡率升高，致密的基质使肿瘤无法有效渗透，并出现化学抗性。最近的研究阐明了 PC 衍生的外泌体通过将关键分子从肿瘤细胞转运到肿瘤微环境 (TME) 中的受体细胞，在驱动和促进 PC 进展、转移和化学抗性中的作用。在这篇综述中，我们描述了一些涉及 TME 免疫抑制和重编程、转移性生态位的建立和耐药性的关键外泌体分子。我们还探索了外泌体作为早期 PC 检测和管理的诊断工具以及治疗靶点的潜力。