Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional strategies are needed to provide a rapid cure for infected individuals. An interesting target for antiviral drugs is the process of viral attachment and entry into the cell. Although most viruses use distinct host receptors for attachment to the target cell, some viruses share receptors, of which sialic acids are a common example. This review aims to give an update on entry inhibitors for a range of sialic-acid-targeting viruses and provides insight into the prospects for those with broad-spectrum potential.

在过去的几十年里，已经开发了几种抗病毒药物来治疗一系列感染。然而，可治疗的病毒感染数量仍然有限，而且对当前药物治疗方案的耐药性是一个日益严重的问题。因此，需要额外的策略来为受感染的个体提供快速治愈。抗病毒药物的一个有趣靶标是病毒附着和进入细胞的过程。虽然大多数病毒使用不同的宿主受体来附着在靶细胞上，但有些病毒共享受体，唾液酸就是一个常见的例子。本综述旨在更新一系列唾液酸靶向病毒的进入抑制剂，并深入了解具有广谱潜力的病毒的前景。