Abstract The present study describes the first electroanalytical investigation and the development of a novel voltammetric method for a sensitive, simple, fast, cheap and eco-friendly determination of eltrombopag (ELT). At a boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic), the compound presented one or two oxidation steps at relatively low positive potentials within the pH range 6.0-12.0 by employing square-wave voltammetry. The sensitivity of the measurements was significantly enhanced with the positive effect of cetyltrimethylammonium bromide (CTAB) under the accumulation condition. In Britton-Robinson buffer pH 12.0 containing 2×10-4 mol L-1 CTAB (after 30 s accumulation at open-circuit condition), there was a linear dependence of peak current at +0.19 V (vs. Ag/AgCl) and ELT concentration in the range of 0.1 - 12.5 μg mL-1 (2.3×10-7 -2.8×10-5 mol L-1) with a detection limit of 0.0125 μg mL-1 (5.7×10-8 mol L-1). The developed approach could be used for ELT determination in commercial tablet formulations.

中文翻译：

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在阳离子表面活性剂存在下，在未修饰的掺硼金刚石电极上对血小板生成素受体激动剂药物艾曲波帕进行首次电分析研究和简单量化

摘要 本研究描述了首次对艾曲波帕 (ELT) 进行灵敏、简单、快速、廉价和环保测定的电分析研究和新型伏安法的开发。在经过电化学（阳极和随后的阴极）预处理的掺硼金刚石电极上，该化合物通过使用方波伏安法在 pH 值范围 6.0-12.0 内在相对较低的正电位下进行一到两个氧化步骤。在积累条件下，十六烷基三甲基溴化铵 (CTAB) 的积极作用显着提高了测量的灵敏度。在包含 2×10-4 mol L-1 CTAB 的 Britton-Robinson 缓冲液 pH 12.0 中（在开路条件下积累 30 秒后），峰值电流在 +0.19 V（相对于 Ag/AgCl) 和 ELT 浓度范围为 0.1 - 12.5 μg mL-1 (2.3×10-7 -2.8×10-5 mol L-1)，检测限为 0.0125 μg mL-1 (5.7×10- 8 摩尔 L-1)。开发的方法可用于商业片剂配方中的 ELT 测定。