Intercellular communication is vital to tumor progression. In this issue of Developmental Cell, Bertolini et al. (2020) describe how small extracellular vesicles released from hypoxic mammary tumor cells facilitate intercellular communication, leading to alterations in mitochondrial dynamics and acquisition of invasive phenotypes in normal epithelial cells.

中文翻译：

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绝命毒师：细胞外囊泡在缺氧条件下引发致瘤反应

细胞间通讯对于肿瘤进展至关重要。在本期《发育细胞》中，Bertolini 等人。(2020)描述了缺氧乳腺肿瘤细胞释放的小细胞外囊泡如何促进细胞间通讯，导致线粒体动力学的改变和正常上皮细胞中侵袭性表型的获得。