当前位置: X-MOL 学术Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
There and back again: The mechanisms of differentiation and transdifferentiation in Drosophila blood cells
Developmental Biology ( IF 2.7 ) Pub Date : 2020-10-23 , DOI: 10.1016/j.ydbio.2020.10.006
Gábor Csordás , Erika Gábor , Viktor Honti

Transdifferentiation is a conversion of an already differentiated cell type into another cell type without the involvement of stem cells. This transition is well described in the case of vertebrate immune cells, as well as in Drosophila melanogaster, which therefore serves as a suitable model to study the process in detail. In the Drosophila larva, the latest single-cell sequencing methods enabled the clusterization of the phagocytic blood cells, the plasmatocytes, which are capable of transdifferentiation into encapsulating cells, the lamellocytes. Here we summarize the available data of the past years on the plasmatocyte-lamellocyte transition, and make an attempt to harmonize them with transcriptome-based blood cell clustering to better understand the underlying mechanisms of transdifferentiation in Drosophila, and in general.



中文翻译:

反复:果蝇血细胞的分化和转分化机制

转分化是一种已经分化的细胞类型向另一种细胞类型的转化,而没有干细胞的参与。这种转变在脊椎动物免疫细胞的情况下以及在果蝇中都得到了很好的描述,因此可以作为合适的模型来详细研究该过程。在果蝇中幼虫,最新的单细胞测序方法使吞噬血细胞(浆细胞)能够聚集,所述吞噬血细胞能够转分化为包囊细胞(层细胞)。在这里,我们总结了过去几年中有关浆细胞​​-弹状细胞转变的可用数据,并尝试将其与基于转录组的血细胞簇相协调,以更好地了解果蝇转分化的潜在机制,以及一般情况。

更新日期:2020-10-30
down
wechat
bug