Necrotizing enterocolitis (NEC) often leads to gastrointestinal emergency resulting high mortality in very low birth weight infants (VLBWIs) requiring surgery. To date, few studies have explored the role of serum cytokines in the development of feeding intolerance (FI) or NEC outcomes in VLBWIs. Infants born weighing <1500 g or of 32 weeks of gestational age were prospectively enrolled from May 2018 to Dec 2019. We measured several cytokines routinely within 72 h of life, even before NEC-like symptoms developed. NEC or FI group comprised 17 (27.4%) infants, and 6 (9.7%) infants had surgical NEC. The gestational age and birth weight were significantly lower in the NEC or FI group with more prematurity-related complications. The surgical NEC group also demonstrated significantly lower gestational age and birth weight along with more infants experiencing refractory hypotension within a 1 week of life, pulmonary hypertension, and patent ductus arteriosus. IL-10 levels were significantly higher in the NEC or FI group, whereas IL-8 levels were significantly higher in the infants with surgical NEC. Our findings indicated to IL-8 can predict surgical NEC while increased IL-10 can predict NEC development in VLBWIs.

中文翻译：

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白细胞介素 8 可预测出生小于 1500 g 婴儿的手术坏死性小肠结肠炎

坏死性小肠结肠炎 (NEC) 通常会导致胃肠道紧急情况，从而导致需要手术的极低出生体重婴儿 (VLBWI) 的高死亡率。迄今为止，很少有研究探讨血清细胞因子在 VLBWI 喂养不耐受 (FI) 或 NEC 结果发展中的作用。从 2018 年 5 月到 2019 年 12 月，出生体重 <1500 g 或胎龄 32 周的婴儿被前瞻性纳入。我们在生命的 72 小时内常规测量了几种细胞因子，甚至在 NEC 样症状出现之前。NEC 或 FI 组包括 17 (27.4%) 名婴儿，6 (9.7%) 名婴儿进行了手术 NEC。早产相关并发症较多的 NEC 或 FI 组的胎龄和出生体重显着较低。手术 NEC 组还表现出显着较低的胎龄和出生体重，以及更多的婴儿在出生后 1 周内出现顽固性低血压、肺动脉高压和动脉导管未闭。NEC 或 FI 组的 IL-10 水平显着更高，而手术 NEC 婴儿的 IL-8 水平显着更高。我们的研究结果表明 IL-8 可以预测手术 NEC，而增加的 IL-10 可以预测 VLBWI 中 NEC 的发展。