OBJECTIVE To investigate how functional integrity of ascending sensory pathways measured by visual and somatosensory evoked potentials (VEP & SEP) is associated with abnormal glycemia and brain injury in newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE). METHODS Fifty-four neonates ≥ 36 weeks gestational age with HIE underwent glucose testing, VEPs, SEPs, and magnetic resonance imaging (MRI) the first week of life. Minimum and maximum glucose values recorded prior to evoked potential (EP) testing were compared with VEP and SEP measures using generalized estimating equations. Relationships between VEP and SEP measures and brain injury on MRI were assessed. RESULTS Maximum glucose is associated with decreased P200 amplitude, and increased odds that N300 peak will be delayed/absent. Minimum glucose is associated with decreased P22 amplitude. Presence of P200 and N300 peaks is associated with decreased odds of brain injury in the visual processing pathway, with delayed/absent N300 peak associated with increased odds of brain injury in posterior white matter. CONCLUSIONS Deviations from normoglycemia are associated with abnormal EPs, and abnormal VEPs are associated with brain injury on MRI in cooled neonates with HIE. SIGNIFICANCE Glucose is a modifiable risk factor associated with atypical brain function in neonates with HIE despite hypothermia treatment.

中文翻译：

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与新生儿缺氧缺血性脑病血糖异常和脑损伤相关的诱发电位异常

目的 研究通过视觉和体感诱发电位 (VEP & SEP) 测量的上行感觉通路的功能完整性如何与因缺氧缺血性脑病 (HIE) 接受低温治疗的新生儿的血糖异常和脑损伤相关。方法 54 名 ≥ 36 周胎龄 HIE 新生儿在出生后第一周接受了血糖检测、VEP、SEP 和磁共振成像 (MRI)。使用广义估计方程将诱发电位 (EP) 测试前记录的最小和最大葡萄糖值与 VEP 和 SEP 测量值进行比较。评估了 VEP 和 SEP 测量值与 MRI 脑损伤之间的关系。结果 最大葡萄糖与 P200 振幅降低有关，并且 N300 峰值延迟/消失的几率增加。最低葡萄糖与降低的 P22 振幅相关。P200 和 N300 峰的存在与视觉处理通路中脑损伤的几率降低有关，延迟/不存在 N300 峰与后白质脑损伤的几率增加有关。结论 与正常血糖的偏差与异常 EP 相关，异常 VEP 与 HIE 冷却新生儿的 MRI 脑损伤相关。意义 葡萄糖是一种可改变的危险因素，与 HIE 新生儿的非典型脑功能相关，尽管进行了低温治疗。结论 与正常血糖的偏差与异常 EP 相关，异常 VEP 与 HIE 冷却新生儿的 MRI 脑损伤相关。意义 葡萄糖是一种可改变的危险因素，与 HIE 新生儿的非典型脑功能相关，尽管进行了低温治疗。结论 与正常血糖的偏差与异常 EP 相关，异常 VEP 与 HIE 冷却新生儿的 MRI 脑损伤相关。意义 葡萄糖是一种可改变的危险因素，与 HIE 新生儿的非典型脑功能相关，尽管进行了低温治疗。