An interactive mixture, i.e. a blend of larger carrier particles with drug particles adhered on their surfaces, is often used in pharmaceutical formulations for promoting powder flow, improving blend uniformity, reducing the segregation risk during manipulation, and improving the solubility of poorly water-soluble drug. Obtaining uniform and stable interactive mixtures require adhesion forces between fine drug and coarse carrier particles to exceed the cohesion forces between drug particles. This work was aimed at developing the methodology measuring the particle adhesion by centrifugation combined with the optical microscopy to predict interactions between components in the mixtures. In the pilot phase, excipient particles were chosen as model substances, both for the preparation of the carrier surface and deposited particles. As expected, our developed methodology was able to map the behaviour of particles on the rugged surfaces and provide the adhesion strength distribution used for comparing different material adhesion. It can also provide a measure of interactive unit stability when the mixture undergoes process treatment characterised by certain mechanical stress.

交互式混合物，即较大的载体颗粒与粘附在其表面上的药物颗粒的混合物，通常用于药物制剂中，以促进粉末流动，改善混合物均匀性，降低操作过程中的偏析风险并提高水溶性差的溶解度药品。要获得均匀稳定的相互作用混合物，需要精细药物和粗载体颗粒之间的粘附力超过药物颗粒之间的粘附力。这项工作旨在开发通过离心结合光学显微镜测量颗粒附着力的方法，以预测混合物中各组分之间的相互作用。在试验阶段，选择赋形剂颗粒作为模型物质，以制备载体表面和沉积颗粒。不出所料 我们开发的方法能够绘制粗糙表面上颗粒的行为，并提供用于比较不同材料粘附力的粘附强度分布。当混合物经过以某些机械应力为特征的过程处理时，它也可以提供交互式单元稳定性的度量。