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Cord Serum Cytokines at Birth and Children's Anxiety/Depression Trajectories from 3 to 8 Years: The EDEN Mother-Child Cohort
Biological Psychiatry ( IF 10.6 ) Pub Date : 2021-03-01 , DOI: 10.1016/j.biopsych.2020.10.009
Cédric Galera , Susana Barbosa , Ophélie Collet , Olfa Khalfallah , Bruno Aouizerate , Anne-Laure Sutter-Dalley , Muriel Koehl , Lucile Capuron , Judith Van der Waerden , Maria Melchior , Sylvana Côté , Barbara Heude , Nicolas Glaichenhaus , Laetitia Davidovic

BACKGROUND Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this area remain limited. The objectives of the study were to describe the network of cord serum cytokines at birth and test whether they are associated with subsequent anxiety and depression symptom trajectories in offspring. METHODS We used data and biological samples from 871 mother-child pairs followed up from pregnancy to 8 years of age and participating in the French mother-child cohort EDEN (a study on the pre- and early postnatal determinants of child health and development). Cord serum cytokines were measured at birth. Children's symptoms of anxiety and depression were assessed with the emotional difficulties subscore of the Strength and Difficulties Questionnaire at ages 3, 5, and 8 years, from which trajectories of anxiety-depression symptoms were derived. RESULTS Results showed a significant association between cord serum interleukin-7 at birth and the trajectories of children's anxiety-depression symptoms between ages 3 to 8 years (adjusted odds ratio, 0.73; 95% confidence interval, 0.57-0.93). The associations considered relevant confounders, including prenatal maternal depressive symptoms. CONCLUSIONS Early immune changes may contribute to subsequent anxiety and depression symptoms in childhood. Beyond the understanding of mechanisms underlying the occurrence of emotional difficulties in children, our findings open avenues for future research in human and animals.

中文翻译:

出生时的脐带血清细胞因子和 3 至 8 岁儿童的焦虑/抑郁轨迹:伊甸园母婴队列

背景 最近的研究表明,怀孕期间的免疫失调可能是后代出现焦虑和抑郁症状的危险因素。尽管动物研究已经证明了围产期细胞因子与后代异常行为之间联系的重要性,但该领域的人类流行病学研究仍然有限。该研究的目的是描述出生时脐带血清细胞因子的网络,并测试它们是否与后代随后的焦虑和抑郁症状轨迹有关。方法 我们使用了 871 对母子对的数据和生物样本,这些母子对从怀孕到 8 岁进行了随访,并参与了法国母子队列 EDEN(一项关于儿童健康和发育的产前和产后早期决定因素的研究)。在出生时测量脐带血清细胞因子。儿童的焦虑和抑郁症状在 3、5 和 8 岁时使用力量和困难问卷的情绪困难子评分进行评估,从中得出焦虑-抑郁症状的轨迹。结果 结果显示,出生时脐带血清白细胞介素 7 与 3 至 8 岁儿童焦虑抑郁症状的轨迹之间存在显着相关性(调整后的优势比,0.73;95% 置信区间,0.57-0.93)。这些协会考虑了相关的混杂因素,包括产前母亲的抑郁症状。结论 早期的免疫变化可能会导致儿童随后出现焦虑和抑郁症状。除了了解儿童情绪困难发生的潜在机制之外,
更新日期:2021-03-01
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