Inflammatory bowel disease (IBD) is an important chronic condition associated with the infection affecting the gastrointestinal tract (G.I.) in dogs. Several factors’ viz. gastrointestinal tract lymphoid tissue (GALT), permeability defects, genetic, ischemic, biochemical, psychosomatic disorders, infectious and parasitic agents, dietary allergies, and adverse drug reactions are associated with inflammatory bowel disease. The most noticeable clinical signs are vomiting, diarrhea, changes in appetite, weight loss, anorexia, ascites and peripheral edema. Nitric oxide (NO), a pleiotropic free radical messenger molecule plays an immense role in playing mucosal inflammation in the intestine through activation of NO synthase enzyme (iNOS). The complex mechanism associated with inflammation in the G.I. tract is also correlated with the expression of iNOS, enzymatic activity, and NO production. NO exerts a beneficial role in maintaining epithelial permeability as well as the immune response in acute colitis. But the excessive production of NO causes adverse effects. In the review, the author suggests that a complex phenomenon is associated with competing biochemical pathways triggered by NO through the regulation of mucosal inflammation in inflammatory bowel disease. This review is a unique compilation about the role of NO in the pathogenesis of inflammatory bowel disease of the dogs.

炎症性肠病 (IBD) 是一种重要的慢性疾病，与影响狗的胃肠道 (GI) 的感染有关。几个因素即。胃肠道淋巴组织 (GALT)、通透性缺陷、遗传、缺血、生化、心身疾病、感染和寄生虫、饮食过敏和药物不良反应都与炎症性肠病有关。最显着的临床症状是呕吐、腹泻、食欲改变、体重减轻、厌食、腹水和外周水肿。一氧化氮 (NO) 是一种多效性自由基信使分子，通过激活 NO 合酶 (iNOS) 在肠道粘膜炎症中发挥着巨大作用。与胃肠道炎症相关的复杂机制也与 iNOS 的表达相关，酶活性和 NO 的产生。NO 在维持上皮通透性以及急性结肠炎的免疫反应方面发挥有益作用。但过量产生一氧化氮会造成不良影响。在这篇综述中，作者提出一个复杂的现象与 NO 通过调节炎症性肠病中的粘膜炎症引发的竞争性生化途径有关。本综述是关于 NO 在犬炎症性肠病发病机制中作用的独特汇编。作者认为，一种复杂的现象与 NO 通过调节炎症性肠病中的粘膜炎症引发的竞争性生化途径有关。本综述是关于 NO 在犬炎症性肠病发病机制中作用的独特汇编。作者认为，一种复杂的现象与 NO 通过调节炎症性肠病中的粘膜炎症引发的竞争性生化途径有关。本综述是关于 NO 在犬炎症性肠病发病机制中作用的独特汇编。