Stroke is considered a leading cause of mortality and neurological disability, which puts a huge burden on individuals and the community. To date, effective therapy for stroke has been limited by its complex pathological mechanisms. Autophagy refers to an intracellular degrading process with the involvement of lysosomes. Autophagy plays a critical role in maintaining the homeostasis and survival of cells by eliminating damaged or non-essential cellular constituents. Increasing evidence support that autophagy protects neuronal cells from ischemic injury. However, under certain circumstances, autophagy activation induces cell death and aggravates ischemic brain injury. Diverse naturally derived compounds have been found to modulate autophagy and exert neuroprotection against stroke. In the present work, we have reviewed recent advances in naturally derived compounds that regulate autophagy and discussed their potential application in stroke treatment.

中风被认为是导致死亡和神经功能障碍的主要原因，这给个人和社区带来了巨大的负担。迄今为止，卒中的有效治疗受到其复杂病理机制的限制。自噬是指溶酶体参与的细胞内降解过程。自噬通过消除受损或非必需的细胞成分，在维持细胞稳态和存活方面发挥着关键作用。越来越多的证据支持自噬保护神经元细胞免受缺血性损伤。然而，在某些情况下，自噬激活会诱导细胞死亡并加重缺血性脑损伤。已发现多种天然衍生化合物可调节自噬并对中风发挥神经保护作用。在目前的工作中，