A novel zinc complex derived from a multidentate ligand, nitrilotris(ethane-2,1-diyl)tris(azanylylidene)tris(methanylylidene)tris(2-methoxyphenol), was designed and structurally investigated by elemental analyses, IR, NMR, ESI-MS, and UV–Vis studies. The density functional theory was also recorded to investigate the additional insights into the structural and electronic properties of the ligand and its complex. Both the ligand and its complex showed significant neurite outgrowth and viability in brain neuron at lower concentration when investigated for neurological properties. Thus, it can be suggested that the ligand and its complex may play a potential role in brain development, functioning as well as in the treatment of neurological disorders.

Graphic abstract

中文翻译：

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具有多齿配体的锌配合物的合成，结构研究，DFT研究和神经营养活性

设计了一种由多齿配体衍生的新型锌配合物，次氮基三（乙烷-2,1-二基）三（氮杂亚烷基）三（甲亚基）三（2-甲氧基苯酚），并通过元素分析，IR，NMR，ESI- MS和UV-Vis研究。还记录了密度泛函理论，以研究有关配体及其配合物的结构和电子性质的其他见解。当研究神经特性时，配体及其复合物在较低浓度下均在脑神经元中显示出明显的神经突生长和活力。因此，可以认为配体及其复合物可能在脑发育，功能以及神经疾病的治疗中起潜在作用。

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