The generation of a phenotypic diversity that is coherent across a bacterial population is a fundamental problem. We propose here that the DNA strand-specific segregation of certain nucleoid-associated proteins or NAPs results in these proteins being asymmetrically distributed to the daughter cells. We invoke a variety of mechanisms as responsible for this asymmetrical segregation including those based on differences between the leading and lagging strands, post-translational modifications, oligomerisation and association with membrane domains.

中文翻译：

---

假设：类核蛋白与亲本 DNA 链分离以产生一致的表型多样性

在整个细菌种群中产生一致的表型多样性是一个基本问题。我们在这里提出，某些类核蛋白或 NAP 的 DNA 链特异性分离导致这些蛋白质不对称地分布到子细胞中。我们调用了多种机制来负责这种不对称分离，包括基于前导链和滞后链之间的差异、翻译后修饰、寡聚化和与膜域关联的机制。