Surface-enhanced Raman scattering (SERS) has been considered a high sensitivity, specificity, and ultra-fast analytical technique in molecular fingerprint recognition. Herein, a kind of sandwich Au/“star-like” mesoporous SiO₂/Ag (Au/MSiO₂/Ag) hybrid nanostructure was developed by implementing the electrostatic adsorption and magnetron sputtering technology for SERS application. In the experiment, the decoration density of the MSiO₂/Ag nanostructure was conveniently adjusted through tuning the washing times of the silicon wafer in ethanol. The prepared substrate with the optimal geometry structure exhibited an enhancement factor (EF) of 9.2 × 10⁵, a limit of detection (LOD) of 5 × 10⁻⁵ M, and a low relative standard deviation value of 5.02%. In the end, the obtained hybrid SERS substrate was used to detect nitrofurazone and an excellent LOD of 1 ppm was achieved. Overall, our novel sandwich Au/MSiO₂/Ag hybrid SERS substrate provides a rapid and accurate way of monitoring ultra-low trace antibiotics, which can significantly promote food safety.

表面增强拉曼散射（SERS）被认为是分子指纹识别中的高灵敏度，特异性和超快速分析技术。在本文中，通过实现静电吸附和磁控溅射技术用于SERS应用，开发了一种三明治型Au /“星状”介孔SiO ₂ / Ag（Au / MSiO ₂ / Ag）杂化纳米结构。在实验中，通过调节硅片在乙醇中的洗涤时间，可以方便地调节MSiO ₂ / Ag纳米结构的装饰密度。制备的具有最佳几何结构的基材显示出9.2×10 ⁵的增强因子（EF ），5×10 ^-5的检测极限（LOD） M，相对标准偏差低至5.02％。最后，将获得的杂化SERS底物用于检测呋喃西林，并获得了1 ppm的出色LOD。总体而言，我们新颖的三明治式Au / MSiO ₂ / Ag杂化SERS底物为监测超低痕量抗生素提供了一种快速而准确的方法，可显着提高食品安全性。