Abstract

The aim of this work was to study the effect of proton pencil beam scanning in the Bragg peak in the dose range of 0.1–1.5 Gy on the induction of cytogenetic damage in the bone marrow, reactive oxygen species (ROS) production in whole blood, and the state of lymphoid organs after total body irradiation of mice. Irradiation was carried out in the Prometeus proton synchrotron (Protvino) in the Bragg peak with proton energy at the output of 90–116 MeV. It was found that, under irradiation of mice in the range of low and medium doses of proton pencil beam scanning in the Bragg peak, the relative biological effectiveness (RBE) according to the criterion of cytogenetic changes was 1.15. In addition, it was found that the pathophysiological effect on the lymphoid organs and the production of ROS by blood cells were different as compared with the effect of X-rays.

中文翻译：

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中低剂量质子笔扫描束对小鼠全辐照期间造血器官的影响

摘要

这项工作的目的是研究在0.1–1.5 Gy剂量范围内的Bragg峰上进行质子笔束扫描对诱导骨髓细胞遗传损伤，全血中活性氧（ROS）产生的影响，小鼠全身照射后的淋巴器官状态。辐射在布拉格峰的Prometeus质子同步加速器（Protvino）中进行，质子能量在90–116 MeV的输出处进行辐照。结果发现，在布拉格剂量的质子笔束扫描的中，低剂量范围内的小鼠照射下，根据细胞遗传学改变的标准，相对生物学有效性（RBE）为1.15。此外，